Stains & molecular markers
T-bet
Copyright: 2002-2021, PathologyOutlines.com, Inc.
T-bet
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2011
Minor changes: 24 December 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. T-bet. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainstbet.html. Accessed January 19th, 2021.
Definition / general
- Master regulator of helper T cells type 1
- As a transcription factor, also regulates development and cytotoxic function of NK cells
Uses by pathologists
- May be useful to detect minimal hairy cell leukemia infiltrates in bone marrow biopsies (Am J Surg Pathol 2007;31:1181)
- Does not appear to be useful in differentiating hairy cell leukemia from marginal zone lymphoma (Am J Clin Pathol 2011;136:390)
Microscopic (histologic) images
Image hosted on other servers:
Pre-B lymphoblastic
lymphoma of
kidney (left),
skin (right)
Positive staining - normal
- CD4+ T cells, some B cells
Positive staining - disease
- Extranodal NK/T-cell lymphoma, nasal type, and peripheral T-cell lymphoma (Hum Pathol 2011;42:1319)
- Some B cell non-Hodgkin lymphomas (Am J Clin Pathol 2004;122:292)
