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Definition / generalCite this page: Pernick N. Tenascin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainstenascin.html. Accessed January 20th, 2021.
Definition / general
- Also called tenascin C
- Large glycoprotein of extracellular matrix, synthesized by fibroblasts, composed of epidermal growth factor like repetitions
- May function in epithelial-mesenchymal interactions
- Expressed during embryogenesis, growth, wound healing, inflammation
- Increased in carcinoma of Ampulla of Vater, breast, colon, lung, prostate
- Pheochromocytoma: strong expression associated with malignancy (Am J Surg Pathol 2001;25:1419)