Stains & molecular markers
Tenascin
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Tenascin[title]
Tenascin
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 24 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Tenascin[title]
Table of Contents
Definition / generalCite this page: Pernick N. Tenascin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainstenascin.html. Accessed January 22nd, 2021.
Definition / general
- Also called tenascin C
- Large glycoprotein of extracellular matrix, synthesized by fibroblasts, composed of epidermal growth factor like repetitions
- May function in epithelial-mesenchymal interactions
- Expressed during embryogenesis, growth, wound healing, inflammation
- Increased in carcinoma of Ampulla of Vater, breast, colon, lung, prostate
- Pheochromocytoma: strong expression associated with malignancy (Am J Surg Pathol 2001;25:1419)
