Stains & CD markers
Uroplakin III
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Uroplakin III
Uroplakin III
Author: Nat Pernick, M.D.
Last author update: 1 June 2005
Last staff update: 5 September 2023
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Uroplakin III
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Uroplakin III. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsuroplakinIII.html. Accessed April 19th, 2024.
Definition / general
- One of 4 members of uroplakin family
- Transmembrane protein expressed by urothelial lining cells (umbrella cells) within apical plaques of cell membrane
- Specific but only 50% sensitive for urothelial lesions (Am J Surg Pathol 2003;27:1)
Uses by pathologists
- Characterize urothelial lesions and differentiate from prostatic (Hum Pathol 2002;33:1136), penile (Am J Surg Pathol 2012;36:869), vulvar (Hum Pathol 2002;33:545) or renal lesions
- May be applicable for forensic urine identification by immunohistochemistry (J Forensic Sci 2010;55:742)
Microscopic (histologic) images
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Urothelial carcinoma (invasive)
Positive staining - normal
- Urothelium, particularly umbrella cells
Positive staining - disease
- Urothelial lesions
- Ovarian Brenner tumor (Am J Surg Pathol 2003;27:1434)
Negative staining
- Bladder: small cell carcinoma (Am J Surg Pathol 2003;27:1), squamous lesions (Virchows Arch 2011;458:301)
- Prostate: adenocarcinoma
