Stains & molecular markers
Uroplakin III


Topic Completed: 1 June 2005

Minor changes: 24 December 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Uroplakin III[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Uroplakin III. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsuroplakiniii.html. Accessed January 19th, 2021.
Definition / general
  • One of 4 members of uroplakin family
  • Transmembrane protein expressed by urothelial lining cells (umbrella cells) within apical plaques of cell membrane
  • Specific but only 50% sensitive for urothelial lesions (Am J Surg Pathol 2003;27:1)
Uses by pathologists
Microscopic (histologic) images

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Urothelial carcinoma (invasive)

Positive staining - normal
  • Urothelium, particularly umbrella cells
Positive staining - disease
Negative staining
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