Table of ContentsDefinition / general
Cite this page: Pernick N. VEGF. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsvegf.html. Accessed June 2nd, 2020.
Definition / general
- Vascular Endothelial Growth Factor
- Exists in 4 different homodimeric isoforms due to alternate splicing
- Potent angiogenic growth factor that stimulates endothelial cell proliferation and induces microvessel permeability
- Protein and mRNA are overexpressed in various tumors
- May have prognostic significance in esophageal adenocarcinoma (Hum Pathol 2005;36:955)