Stains
Villin
Copyright: 2003-2018, PathologyOutlines.com, Inc.
PubMed Search: Villin[TI]
Villin
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 1 May 2020
Copyright: 2003-2018, PathologyOutlines.com, Inc.
PubMed Search: Villin[TI]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Villin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsvillin.html. Accessed May 24th, 2020.
Definition / general
- Actin binding protein present in cytoskeleton of intestinal microvilli; has critical role in maintaining brush border organization
- Relatively specific for GI epithelium with brush border microvilli or adenocarcinomas derived from them
Uses by pathologists
- Primary bladder adenocarcinoma vs. colorectal carcinoma to bladder - negative CDX2 and negative villin suggests bladder primary (Mod Pathol 2005;18:1217)
- Colorectal adenocarcinoma (villin+) vs. ovarian adenocarcinoma (villin-)
Positive staining - normal
- Digestive tract epithelium, renal proximal tubules, hepatic bile ducts
Positive staining - disease
- Pulmonary adenocarcinomas, renal cell carcinoma, colonic adenocarcinoma (98%)
Negative staining
- Bronchiolar epithelium, pulmonary alveolar cells, bronchial gland cells, renal distal tubules
