Pathology Outlines

Stains
WT1

Author: Nat Pernick, M.D.

Topic Completed: 1 June 2005

Revised: 7 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: WT1[TI] pathology free full text[sb]

Page views in 2018: 17,857

Page views in 2019 to date: 18,869

Table of Contents

Cite this page: Pernick N. WT1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainswt1.html. Accessed November 12th, 2019.

Definition / general

Tumor suppressor gene at 11p13
Protein is transcriptional regulator that apparently inhibits transcription of growth promoting genes
Involved in development of tissues from inner layer of intermediate mesoderm

Interpretation

Nuclear stain

Uses by pathologists

(1) ovarian carcinoma (WT1+) vs. breast/pancreatic carcinoma (WT1 negative)

Positive staining - normal

Fallopian tube, kidney, mesothelium, ovarian granulosa cells, Sertoli cells, spleen

Positive staining - disease

Acute myeloid leukemia, cystic partially differentiated nephroblastoma, desmoplastic small round cell tumor, malignant mesothelioma, metanephric adenoma, nephrogenic rests, ovarian carcinomas (serous carcinoma [almost all], transitional, small cell, Am J Surg Pathol 2005;29:1034), peritoneal serous carcinoma involving an endometrial polyp-80% (Am J Surg Pathol 2005;29:1074), rhabdoid tumor, Wilm tumor

Negative staining

Endometrial glands, ovarian mucinous and clear cell carcinomas (Arch Pathol Lab Med 2005;129:85)

Microscopic (histologic) images

Images hosted on other servers:

Metanephric adenoma (fig D)

Ovarian tumor subtypes