Stains & molecular markers
WT1
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: WT1[TI] pathology free full text[sb]
WT1
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 22 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: WT1[TI] pathology free full text[sb]
Table of Contents
Definition / general | Interpretation | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative staining | Microscopic (histologic) imagesCite this page: Pernick N. WT1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainswt1.html. Accessed April 18th, 2021.
Definition / general
- Tumor suppressor gene at 11p13
- Protein is transcriptional regulator that apparently inhibits transcription of growth promoting genes
- Involved in development of tissues from inner layer of intermediate mesoderm
Interpretation
- Nuclear stain
Uses by pathologists
- (1) ovarian carcinoma (WT1+) vs. breast/pancreatic carcinoma (WT1 negative)
Positive staining - normal
- Fallopian tube, kidney, mesothelium, ovarian granulosa cells, Sertoli cells, spleen
Positive staining - disease
- Acute myeloid leukemia, cystic partially differentiated nephroblastoma, desmoplastic small round cell tumor, malignant mesothelioma, metanephric adenoma, nephrogenic rests, ovarian carcinomas (serous carcinoma [almost all], transitional, small cell, Am J Surg Pathol 2005;29:1034), peritoneal serous carcinoma involving an endometrial polyp-80% (Am J Surg Pathol 2005;29:1074), rhabdoid tumor, Wilm tumor
Negative staining
- Endometrial glands, ovarian mucinous and clear cell carcinomas (Arch Pathol Lab Med 2005;129:85)
Microscopic (histologic) images
Contributed by Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.
Ovarian serous carcinoma immunoprofile
