Stains & molecular markers

Topic Completed: 1 June 2005

Minor changes: 22 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: WT1[TI] pathology free full text[sb]

Nat Pernick, M.D.
Page views in 2020: 25,634
Page views in 2021 to date: 8,473
Cite this page: Pernick N. WT1. website. Accessed April 18th, 2021.
Definition / general
  • Tumor suppressor gene at 11p13
  • Protein is transcriptional regulator that apparently inhibits transcription of growth promoting genes
  • Involved in development of tissues from inner layer of intermediate mesoderm
  • Nuclear stain
Uses by pathologists
  • (1) ovarian carcinoma (WT1+) vs. breast/pancreatic carcinoma (WT1 negative)
Positive staining - normal
  • Fallopian tube, kidney, mesothelium, ovarian granulosa cells, Sertoli cells, spleen
Positive staining - disease
  • Acute myeloid leukemia, cystic partially differentiated nephroblastoma, desmoplastic small round cell tumor, malignant mesothelioma, metanephric adenoma, nephrogenic rests, ovarian carcinomas (serous carcinoma [almost all], transitional, small cell, Am J Surg Pathol 2005;29:1034), peritoneal serous carcinoma involving an endometrial polyp-80% (Am J Surg Pathol 2005;29:1074), rhabdoid tumor, Wilm tumor
Negative staining
Microscopic (histologic) images

Contributed by Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.

Ovarian serous carcinoma immunoprofile

Back to top
Image 01 Image 02