Stomach
Hypertrophic gastropathy
Zollinger-Ellison


Topic Completed: 1 August 2012

Minor changes: 1 September 2020

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PubMed Search: Zollinger-Ellison syndrome

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Zollinger-Ellison. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachZE.html. Accessed May 15th, 2021.
Definition / general
  • Duodenal ulceration, diarrhea and gastric gland hyperplasia caused by serum hypergastrinemia from pancreatic or duodenal neoplasm, or rarely by primary G cell hyperplasia of antral mucosa
  • Grossly and radiologically resembles Menetrier's disease
  • Associated with MEN1 syndrome and multicentric carcinoid tumors (Am J Surg Pathol 1990;14:503)
  • Intramucosal cysts in body in 70%, may give rise to fundic gland polyps, severity associated with serum gastrin levels (Hum Pathol 2000;31:140)
Gross description
  • Enlarged fundic mucosal folds with cerebriform pattern
Microscopic (histologic) description
  • Hyperplasia primarily of parietal cells in fundic glands
  • Normal antral glands and gastric pits, often increase in enterochromaffin-like cells
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