Eosinophilic gastritis

Topic Completed: 1 July 2012

Minor changes: 4 October 2021

Copyright: 2003-2021,, Inc.

PubMed Search: eosinophilic (allergic) gastroenteritis

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Eosinophilic gastritis. website. Accessed October 15th, 2021.
Definition / general
  • Usually children or young adults with vomiting, diarrhea, protein losing enteropathy, food sensitivity, growth failure
  • Also allergic history, anemia, blood eosinophilia, increased serum IgE
  • Stomach most common site, but primary eosinophilic gastritis without involvement of esophagus or duodenum is uncommon; symptoms relate to site
  • Either mucosal, mural or serosal disease; mucosal biopsies may be normal when disease is primarily mural or serosal
  • Ascites with eosinophilia may occur with serosal disease
  • Often have positive skin tests but no anaphylactic reactions, suggestive of type IV hypersensitivity
  • Formerly known as allergic gastritis
  • Steroids, diet modification, but may have multiple relapses
Microscopic (histologic) description
  • Mucosal disease: diffuse and marked eosinophils in mucosa of antrum, focally in fundus / body
Microscopic (histologic) images

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Dense eosinophilic infiltrate of lamina propria

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