Stomach
Neuroendocrine tumors
NET G1 variants


Topic Completed: 1 August 2012

Minor changes: 2 October 2020

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PubMed Search: Enterochromaffin-like cell neuroendocrine tumors

Related Topic: NET G1 (carcinoid tumor)

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. NET G1 variants. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachcarcinoideclcellnets.html. Accessed May 15th, 2021.
Clear cell variant
  • EM: dense core neurosecretory granules
ECL cell variant (Enterochromaffin-like cell neuroendocrine tumors)
  • Tropic effect from gastrin, related to long standing elevated gastrin levels from gastrinoma or gastric gastrin cells responding to achlorhydria
  • Multiple, polypoid, throughout fundus
  • Usually associated with ECL cell hyperplasia and may be difficult to distinguish from hyperplasia
Gastrin producing variant
  • Solitary, usually in antrum, more common in duodenum
  • Positive for gastrin staining but gastrin staining in the absence of sequelae of Zollinger-Ellison syndrome is insufficient to diagnose
  • ACTH producing NET is very rare
Case reports
Gross description
  • Clear cell variant: yellow, resembles gastric xanthoma
Microscopic (histologic) description
  • Clear cell variant: uniform clusters of polygonal cells with foamy cytoplasm; abundant vascular stroma; Chromogranin A positive
  • ECL cell NETs: smooth muscle proliferation, associated with atrophic gastritis with intestinal metaplasia
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