Neuroendocrine tumors

NET G1 variants

Last author update: 1 August 2012
Last staff update: 2 October 2020

Copyright: 2003-2023,, Inc.

PubMed Search: Enterochromaffin-like cell neuroendocrine tumors

Related Topic: NET G1 (carcinoid tumor)

Elliot Weisenberg, M.D.
Page views in 2022: 2,479
Page views in 2023 to date: 2,732
Cite this page: Weisenberg E. NET G1 variants. website. Accessed November 28th, 2023.
Clear cell variant
  • EM: dense core neurosecretory granules
ECL cell variant (Enterochromaffin-like cell neuroendocrine tumors)
  • Tropic effect from gastrin, related to long standing elevated gastrin levels from gastrinoma or gastric gastrin cells responding to achlorhydria
  • Multiple, polypoid, throughout fundus
  • Usually associated with ECL cell hyperplasia and may be difficult to distinguish from hyperplasia
Gastrin producing variant
  • Solitary, usually in antrum, more common in duodenum
  • Positive for gastrin staining but gastrin staining in the absence of sequelae of Zollinger-Ellison syndrome is insufficient to diagnose
  • ACTH producing NET is very rare
Case reports
Gross description
  • Clear cell variant: yellow, resembles gastric xanthoma
Microscopic (histologic) description
  • Clear cell variant: uniform clusters of polygonal cells with foamy cytoplasm; abundant vascular stroma; Chromogranin A positive
  • ECL cell NETs: smooth muscle proliferation, associated with atrophic gastritis with intestinal metaplasia
Back to top
Image 01 Image 02