Carcinoma variants

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Last staff update: 23 April 2021

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PubMed Search: stomach adenosquamous carcinoma

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Carcinoma variants. website. Accessed September 26th, 2023.
Adenosquamous carcinoma
  • Rare; neoplastic squamous component at least 25% of tumor
  • Generally poor prognosis
  • Behavior determined by glandular component
  • Microscopic description: by definition, neoplastic squamous component at least 25% of tumor; generally transitional zone between squamous and glandular component; lymphovascular invasion common
  • Positive stains: CD44 (squamous component) (Arch Pathol Lab Med 2000;124:212)
  • Rare, very aggressive tumor with glandular and malignant spindle cell components
  • 62 year old woman (Oncol Lett 2012;4:53)
Malignant rhabdoid tumor
  • Rare aggressive tumor; usually death within 1 - 6 months after surgery (Am J Surg Pathol 1993;17:813)
  • Microscopic description: solid, diffuse or alveolar growth of tumor cells with poor or no cohesiveness, large polygonal cells with eosinophilic cytoplasmic inclusions that indent nucleus
  • Positive stains: keratin, vimentin
  • Rare, < 50 cases reported
  • Also called parietal cell / gland carcinoma
  • Elderly patients, ages 58 - 81 years
  • Resembles parietal cells but antiparietal cell antibodies often nonreactive (Am J Surg Pathol 2002;26:458)
  • Cases from other studies may have parietal cell origin, but need antiparietal cell antibody testing
  • Microscopic description: moderate to well differentiated adenocarcinoma with sheets of cells with abundant eosinophilic, finely granular cytoplasm resembling parietal cells
  • Positive stains: PTAH, Luxol fast blue
  • Negative stains: PAS, Alcian blue, MUC2 (rare cells may be positive)
  • Electron microscopy description: abundant mitochondria, tubulovesicles, intracellular canaliculi, intercellular lumina with long microvilli
Squamous cell carcinoma
  • By definition, must be surrounded on all sides by gastric mucosa; otherwise may be esophageal carcinoma with gastric extension
  • Usually have small glandular component if searched for
  • Mucoepidermoid carcinoma: very rare
  • Undifferentiated carcinoma: very rare
  • Endodermal sinus tumor: very rare
  • Embryonal carcinoma: very rare
  • Case report of tumor in gastric stump (Am J Surg Pathol 1989;13:317)
Microscopic (histologic) images

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Sarcomatoid component

component and

Lymph node with metastases



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