Stomach
Carcinoma
Carcinoma variants
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 23 April 2021
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: stomach adenosquamous carcinoma
Table of Contents
Adenosquamous carcinoma | Carcinosarcoma | Malignant rhabdoid tumor | Oncocytic | Squamous cell carcinoma | Microscopic (histologic) imagesCite this page: Weisenberg E. Carcinoma variants. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachcarcinomavariants.html. Accessed September 26th, 2023.
Adenosquamous carcinoma
- Rare; neoplastic squamous component at least 25% of tumor
- Generally poor prognosis
- Behavior determined by glandular component
- Microscopic description: by definition, neoplastic squamous component at least 25% of tumor; generally transitional zone between squamous and glandular component; lymphovascular invasion common
- Positive stains: CD44 (squamous component) (Arch Pathol Lab Med 2000;124:212)
Carcinosarcoma
- Rare, very aggressive tumor with glandular and malignant spindle cell components
- 62 year old woman (Oncol Lett 2012;4:53)
Malignant rhabdoid tumor
- Rare aggressive tumor; usually death within 1 - 6 months after surgery (Am J Surg Pathol 1993;17:813)
- Microscopic description: solid, diffuse or alveolar growth of tumor cells with poor or no cohesiveness, large polygonal cells with eosinophilic cytoplasmic inclusions that indent nucleus
- Positive stains: keratin, vimentin
Oncocytic
- Rare, < 50 cases reported
- Also called parietal cell / gland carcinoma
- Elderly patients, ages 58 - 81 years
- Resembles parietal cells but antiparietal cell antibodies often nonreactive (Am J Surg Pathol 2002;26:458)
- Cases from other studies may have parietal cell origin, but need antiparietal cell antibody testing
- Microscopic description: moderate to well differentiated adenocarcinoma with sheets of cells with abundant eosinophilic, finely granular cytoplasm resembling parietal cells
- Positive stains: PTAH, Luxol fast blue
- Negative stains: PAS, Alcian blue, MUC2 (rare cells may be positive)
- Electron microscopy description: abundant mitochondria, tubulovesicles, intracellular canaliculi, intercellular lumina with long microvilli
Squamous cell carcinoma
- By definition, must be surrounded on all sides by gastric mucosa; otherwise may be esophageal carcinoma with gastric extension
- Usually have small glandular component if searched for
- Mucoepidermoid carcinoma: very rare
- Undifferentiated carcinoma: very rare
- Endodermal sinus tumor: very rare
- Embryonal carcinoma: very rare
- Case report of tumor in gastric stump (Am J Surg Pathol 1989;13:317)
Microscopic (histologic) images
Images hosted on other servers:
Carcinosarcoma:
Sarcomatoid component
Sarcomatoid
component and
adenocarcinoma
Lymph node with metastases
Vimentin+
CD57+
