Stomach
Polyps
Cowden


Topic Completed: 1 August 2012

Minor changes: 28 December 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Cowden syndrome

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Cowden. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachcowdens.html. Accessed May 15th, 2021.
Definition / general
  • Also known as multiple hamartoma syndrome
  • Due to rare autosomal dominant germline mutation in PTEN on 10q23
  • Tricholemmomas on face, acral keratoses, oral papillomas, GI polyps that may occur in stomach, small intestine or colon (35 - 40%), increased incidence of breast and thyroid carcinomas, also endometrial and renal cell carcinomas
Gross description
  • Small (1 - 2 mm), sessile polyps
Microscopic (histologic) description
  • Excess lamina propria splayed and dissected into lobules by disorganized fascicles of muscularis mucosa running upward from base of mucosa
Microscopic (histologic) images

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Gastric and colonic polyps

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