IBD-related gastritis

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Last staff update: 28 December 2020

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PubMed Search: Crohn's disease gastritis

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. IBD-related gastritis. website. Accessed September 26th, 2023.
Crohn's disease
  • Clinical involvement rare, microscopic disease is more common
  • Gastric granulomas in 9-15%
  • High proportion of Crohn's patients show upper GI involvement,usually antral (Virchows Arch 1998;432:49)
  • Focal acute inflammation in a background of non-inflamed, H. pylori negative mucosa is suggestive of Crohn's disease (Am J Surg Pathol 1998;22:383, Gut 1996;38:379)
  • Active inflammation in 56% (some inflammatory changes in up to 70%), but only 10% are H. pylori positive
Ulcerative colitis
Microscopic (histologic) description
  • Most common upper GI inflammatory pattern is focal gastritis, followed by gastric basal mixed inflammation and superficial plasmacytosis (Am J Surg Pathol 2010;34:1672)
  • Variable changes in ulcerative colitis include multiple tiny shallow ulcers, crypt abscess formation, increased intraepithelial lymphocytes, villous blunting; microscopic findings parallel remissions and relapses of colonic inflammation
Microscopic (histologic) images

Images hosted on other servers:

Focal lesion in
atral mucosa
resembling active
Crohn's disease

Differential diagnosis
  • Granulomas of Crohn's disease:
    • Foreign-body
    • Fungus
    • Granulomatous gastritis
    • Sarcoid
    • Tuberculosis
    • Tumor
    • Whipple’s disease
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