Topic Completed: 1 August 2012

Minor changes: 1 September 2020

Copyright: 2003-2021,, Inc.

PubMed Search: stomach hepatoid adenocarcinoma

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Hepatoid. website. Accessed November 29th, 2021.
Definition / general
  • Subtype with hepatocellular differentiation and poor prognosis
Gross description
  • Nodular or massive growth, extensive venous invasion
Microscopic (histologic) description
  • Glandular and hepatocellular differentiation
  • Abundant cytoplasmic glycogen, hyaline globules
  • May have tubulopapillary pattern with clear cells
  • May secrete bile
Positive stains
  • AFP in serum
  • Hepatic paraffin antigen AFP (50%, positive in classic gastric adenocarcinomas also)
  • Polyclonal CEA (canalicular pattern)
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