Hypertrophic gastropathy

Hypertrophic hypersecretory gastropathy

Last author update: 1 August 2012
Last staff update: 1 September 2020

Copyright: 2003-2023,, Inc.

PubMed Search: hypertrophic hypersecretory gastropathy

Elliot Weisenberg, M.D.
Page views in 2022: 2,722
Page views in 2023 to date: 2,356
Cite this page: Weisenberg E. Hypertrophic hypersecretory gastropathy. website. Accessed September 30th, 2023.
Definition / general
  • Nodular thickenings of gastric mucosa with acid hypersecretion and often peptic ulceration that is not associated with gastrin secreting tumor
  • Very rare
  • Cases with protein loss resemble Menetrier's disease, but also have hypergastrinemia
  • Cases without protein loss are similar to Zollinger-Ellison syndrome, but no pancreatic tumors, no G cell hyperplasia, no hypergastrinemia
  • May be caused by parietal cells that are overly sensitive to normal serum gastrin levels
Microscopic (histologic) description
  • Glandular hyperplasia with normal foveolae
  • May have peptic ulcer disease
Back to top
Image 01 Image 02