Hypertrophic gastropathy

Hypertrophic hypersecretory gastropathy

Topic Completed: 1 August 2012

Minor changes: 1 September 2020

Copyright: 2003-2021,, Inc.

PubMed Search: hypertrophic hypersecretory gastropathy

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Hypertrophic hypersecretory gastropathy. website. Accessed November 29th, 2021.
Definition / general
  • Nodular thickenings of gastric mucosa with acid hypersecretion and often peptic ulceration that is not associated with gastrin secreting tumor
  • Very rare
  • Cases with protein loss resemble Menetrier's disease, but also have hypergastrinemia
  • Cases without protein loss are similar to Zollinger-Ellison syndrome, but no pancreatic tumors, no G cell hyperplasia, no hypergastrinemia
  • May be caused by parietal cells that are overly sensitive to normal serum gastrin levels
Microscopic (histologic) description
  • Glandular hyperplasia with normal foveolae
  • May have peptic ulcer disease
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