Stomach
Hypertrophic gastropathy
Hypertrophic hypersecretory gastropathy
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 1 September 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: hypertrophic hypersecretory gastropathy
Cite this page: Weisenberg E. Hypertrophic hypersecretory gastropathy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachhypertrophichypersec.html. Accessed September 30th, 2023.
Definition / general
- Nodular thickenings of gastric mucosa with acid hypersecretion and often peptic ulceration that is not associated with gastrin secreting tumor
- Very rare
- Cases with protein loss resemble Menetrier's disease, but also have hypergastrinemia
- Cases without protein loss are similar to Zollinger-Ellison syndrome, but no pancreatic tumors, no G cell hyperplasia, no hypergastrinemia
- May be caused by parietal cells that are overly sensitive to normal serum gastrin levels
Microscopic (histologic) description
- Glandular hyperplasia with normal foveolae
- May have peptic ulcer disease
