Inflammatory fibroid polyp

Editorial Board Member: Catherine E. Hagen, M.D.
Editor-in-Chief: Debra L. Zynger, M.D.
Naziheh Assarzadegan, M.D.
Raul S. Gonzalez, M.D.

Last author update: 5 March 2021
Last staff update: 9 August 2023

Copyright: 2002-2023,, Inc.

PubMed Search: Stomach (inflammatory fibroid polyp [title])

Naziheh Assarzadegan, M.D.
Raul S. Gonzalez, M.D.
Page views in 2022: 18,814
Page views in 2023 to date: 17,789
Cite this page: Assarzadega N, Gonzalez RS. Inflammatory fibroid polyp. website. Accessed September 30th, 2023.
Definition / general
  • Benign neoplastic polyp that occurs anywhere in gastrointestinal tract but most commonly in stomach and small intestine
Essential features
  • Benign mesenchymal gastrointestinal polyp that arises in the submucosa
  • Associated with PDGFRA mutation
  • Usually arises in pylorus or distal antrum in stomach
Clinical features
  • Peak incidence in sixth or seventh decade of life
  • No endoscopic surveillance is required after the histological diagnosis is confirmed
  • Rarely associated with adenocarcinoma or adenoma (Arch Pathol Lab Med 1988;112:829)
Case reports
  • 79 year old woman with chronic gastritis and a 2 cm sessile gastric polyp (Case #421)
  • Local excision
Gross description
  • Typically solitary, small and sessile
  • Median size 1.5 cm but can measure up to 9 cm
Microscopic (histologic) description
  • Submucosal lesion composed of spindle and stellate stromal cells
  • Loose edematous stroma containing thin walled blood vessels with characteristic onion skin arrangement of spindled cells around vessels
  • Inflammatory infiltrate rich in eosinophils
  • Can infiltrate lamina propria
  • Minimal mitotic activity
Microscopic (histologic) images

Contributed by Naziheh Assarzadegan, M.D.

Submucosal mass

Spindle and stellate stromal cells


Case #421

Polypoid mass expanding the submucosa

Mixed inflammatory infiltrate in fibromyxoid stroma, rich in eosinophils

Loose, fibromyxoid spindled stroma

CD34+ stromal cells with onion skinning

Stroma is CD117-,
with scattered
CD117+ mast cells

Positive stains
Negative stains
Molecular / cytogenetics description
  • Associated with activating mutation in the platelet derived growth factor receptor alpha (PDGFRA) gene, supporting a neoplastic origin (Histopathology 2012;61:59)
Sample pathology report
  • Stomach, antrum, polypectomy:
    • Inflammatory fibroid polyp (3.1 cm), focally extending to deep margin (see comment)
    • Lateral margins unremarkable.
    • Comment: An immunohistochemical stain for CD34 is positive.
Differential diagnosis
Board review style question #1

Which of the following statements is true about gastric inflammatory fibroid polyp?

  1. Associated with activating mutation in the platelet derived growth factor receptor alpha gene
  2. Benign and nonneoplastic
  3. Synonymous with inflammatory polyp
  4. Typically centered in the muscularis propria
Board review style answer #1
A. They are associated with activating mutation in the platelet derived growth factor receptor alpha gene

Comment Here

Reference: Inflammatory fibroid polyp
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