Intestinal type

Topic Completed: 1 August 2012

Minor changes: 14 June 2021

Copyright: 2003-2021,, Inc.

PubMed Search: intestinal type adenocarcinoma

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Intestinal type. website. Accessed November 29th, 2021.
Definition / general
  • Bulky tumors composed of glandular structures
  • Mean age 55 years, 2 / 3 men
  • Incidence has declined in last 50 years
  • More common in high risk areas
  • Risk factors: diet containing nitrates, smoked and salted foods, pickled vegetables, lack of citrus fruit, lack of green leafy vegetable; also low socioeconomic status, cigarette smoking [RR: 1.5 - 3.0x]
  • Host factors: chronic gastritis (intestinal metaplasia is a precursor lesion), H. pylori infection, autoimmune gastritis, partial gastrectomy (favors reflux), gastric adenomas
  • Other risk factors: slightly increased risk with blood group A, family history, hereditary nonpolyposis colon cancer syndrome
  • Not a risk factor: alcohol, antacids, occupational exposure
Microscopic (histologic) description
  • Neoplastic intestinal glands resembling colonic adenocarcinoma
  • Contain apical mucin vacuoles
  • Variable calcification, endocrine cells, rare Paneth cells
  • Well differentiated: columnar cells secrete mucin, rarely are ciliated; may mimic complete intestinal metaplasia and need multiple biopsies, but carcinoma has tubules with branching, tortuous, anastomosing and plexiform structures (Hum Pathol 1999;30:826)
  • Poorly differentiated: solid pattern
Microscopic (histologic) images

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Various images

Positive stains
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