Stromal / other tumors

Topic Completed: 1 September 2017

Minor changes: 22 March 2019

Copyright: 2017-2019,, Inc.

PubMed Search: stomach leiomyosarcoma [title]

Raul S. Gonzalez, M.D.
Page views in 2019: 827
Page views in 2020 to date: 404
Cite this page: Gonzalez RS. Leiomyosarcoma. website. Accessed August 6th, 2020.
Definition / general
  • Malignant smooth muscle sarcoma that arises from the muscularis propria of the stomach
  • Accounts for 1% of all malignant tumors of the stomach
Clinical features
Prognostic factors
Case reports
  • 50 year old woman with hypertension and diabetes presented with a submucosal gastric mass (Case of the Week #438)
Gross images

Images hosted on other servers:

Large gastric leiomyosarcoma (>8 cm)

Microscopic (histologic) description
Microscopic (histologic) images

Case of the Week #438, contributed by Dr. Zainab Harb, Salmaniya Medical Complex (Bahrain)






Positive stains
Negative stains
Board review style question #1
Which of the following is a poor prognostic indicator for this neoplasm?

A. Greater than 20 mitoses per 10 high power fields
B. Ki67 proliferative index above 50%
C. Size greater than 5 cm
D. Tumor necrosis
Board review answer #1
C. Size greater than 5 cm

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