Stomach
Neuroendocrine tumors
Poorly differentiated neuroendocrine carcinoma
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 1 September 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Poorly differentiated neuroendocrine carcinoma stomach
Table of Contents
Definition / general | Case reports | Gross description | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Weisenberg E. Poorly differentiated neuroendocrine carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachneuroendocrine.html. Accessed June 2nd, 2023.
Definition / general
- Mean age 70 years (range 44 - 92 years), 70% men
- Poorer prognosis than nonneuroendocrine carcinomas
- May have a poor outcome in MEN1 patients (Am J Surg Pathol 1997;21:1075)
- Small cell and large cell neuroendocrine carcinomas have similar prognosis (Arch Pathol Lab Med 1998;122:1010)
- Small cell variant resembles counterpart in lung; has aggressive clinical course but treatment may be effective (J Surg Oncol 2012;106:994)
- Most gastric carcinomas contain scattered cells (small percentage of tumor) with neuroendocrine differentiation (Arch Pathol Lab Med 1996;120:478) - don't call them neuroendocrine carcinomas
Case reports
- 68 year old man with small cell carcinoma of stomach (Case Rep Gastroenterol 2010;4:298)
Gross description
- Ulcerated or fungated
Microscopic (histologic) description
- Solid, organoid, trabecular, pseudoglandular, spindle cell or rosette-like patterns
- Small cell or large cell patterns
Microscopic (histologic) images
Images hosted on other servers:
Small, round
lymphocyte-like
cells with hyper-
chromatic nuclei
