Stomach
Other tumors
Schwannoma


Topic Completed: 1 July 2012

Minor changes: 2 September 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: gastric schwannoma

Elliot Weisenberg, M.D.
Page views in 2020: 2,294
Page views in 2021 to date: 1,030
Cite this page: Weisenberg E. Schwannoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachschwannoma.html. Accessed May 15th, 2021.
Definition / general
  • Well circumscribed, benign nerve sheath tumor (also called neurilemmoma), much less common (~ 1 / 50) in stomach than GIST
Case reports
  • 37 year old man with incidentally detected gastric mass (Case #455)
  • 46 year old woman with stomach mass (Case #347)
Microscopic (histologic) description
  • Well circumscribed but not encapsulated, with interlacing bundles of spindle cells and collagen
  • Often nuclear pallisading, Verocay bodies, hyalinized vessels
  • May have nuclear atypia, inflammatory cells, peripheral cuff of lymphoid aggregates
  • No mitotic figures, no skenoid fibers, no epithelioid features
Microscopic (histologic) images

Case #455


Microcystic variant of schwannoma in stomach


S100, microcystic variant

CD117, microcystic variant



Case #347

46 year old woman

Positive stains
Negative stains
Board review style question #1
Which of the following describes the majority of schwannomas arising in the gastrointestinal tract?

A. Both encapsulated and circumscribed
B. Circumscribed but not encapsulated
C. Encapsulated but not circumscribed
D. Neither encapsulated nor circumscribed

Board review style answer #1
B. Circumscribed but not encapsulated

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