Other tumors


Last author update: 1 July 2012
Last staff update: 9 March 2023

Copyright: 2003-2023,, Inc.

PubMed Search: gastric schwannoma

Elliot Weisenberg, M.D.
Page views in 2022: 3,390
Page views in 2023 to date: 4,727
Cite this page: Weisenberg E. Schwannoma. website. Accessed September 30th, 2023.
Definition / general
  • Well circumscribed, benign nerve sheath tumor (also called neurilemmoma), much less common (~ 1 / 50) in stomach than GIST
Case reports
  • 37 year old man with incidentally detected gastric mass (Case #455)
  • 46 year old woman with stomach mass (Case #347)
Microscopic (histologic) description
  • Well circumscribed but not encapsulated, with interlacing bundles of spindle cells and collagen
  • Often nuclear pallisading, Verocay bodies, hyalinized vessels
  • May have nuclear atypia, inflammatory cells, peripheral cuff of lymphoid aggregates
  • No mitotic figures, no skenoid fibers, no epithelioid features
Microscopic (histologic) images

Contributed by @RaulSGonzalezMD on Twitter and Cases #455 and #347
Schwannoma Schwannoma Schwannoma Schwannoma


Microcystic variant of schwannoma in stomach

S100, microcystic variant

CD117, microcystic variant

46 year old woman

Positive stains
Negative stains
Board review style question #1
Which of the following describes the majority of schwannomas arising in the gastrointestinal tract?

  1. Both encapsulated and circumscribed
  2. Circumscribed but not encapsulated
  3. Encapsulated but not circumscribed
  4. Neither encapsulated nor circumscribed
Board review style answer #1
B. Circumscribed but not encapsulated

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Reference: Schwannoma
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