Stomach
Other nonneoplastic
Chemotherapy/radiation-induced gastropathy
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 2 October 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Atypia following hepatic arterial infusion chemotherapy
Cite this page: Weisenberg E. Chemotherapy/radiation-induced gastropathy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachte.html. Accessed September 26th, 2023.
Definition / general
- Also called postchemotherapy / radiation therapy changes
- Occurs in 8% of patients with chemoradiation therapy for esophageal carcinoma, may be confused with dysplasia
- Also occurs after hepatic artery infusion chemotherapy (Am J Surg Pathol 1983;7:261, Mod Pathol 2001;14:389)
- After preoperative chemotherapy, may see reduction in tumor cellularity, increase in dense fibrosis, formation of large mucin pools with lymphocytes and macrophages
- In signet ring carcinomas, see smaller intracytoplasmic mucin vacuoles
- Often see no effect (Arch Pathol Lab Med 1991;115:807)
Gross description
- Flat appearance
Microscopic (histologic) description
- Patchy distribution, foveolar and gland involvement, surface maturation, open nuclear chromatin pattern with prominent nucleoli, retention of nuclear polarity, mitoses confined to pits
- May have bizarre nuclear atypia, endarteritis obliterans
- No atypical mitoses, no cytoplasmic eosinophilia, no vacuolization, no intestinal metaplasia, no irregular glandular microcystic change, no increased nuclear/cytoplasmic ratio
- p53-, MIB1+ only in deep foveolar epithelium
