Testis & epididymis
Congenital adrenal hyperplasia

Topic Completed: 1 September 2012

Minor changes: 8 September 2020

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PubMed Search: Congenital adrenal hyperplasia [title] men

Turki Al-Hussain, M.D.
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Table of Contents
Definition / general
Cite this page: Al-Hussain T. Congenital adrenal hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testisCAH.html. Accessed January 22nd, 2021.
Definition / general
  • Autosomal recessive, due to various enzymatic defects that cause different patterns of synthesis of glucocortical, mineralocorticoid and sex hormone synthesis
  • Genetic males have cryptorchidism, viable Wolffian duct structures, female or ambiguous genitalia, no Müllerian duct structures
  • Testes resemble cryptorchid testes
  • May have bilateral Leydig cell hyperplasia with deficiencies of 21-hydroxylase, 11β hydroxylase, 17α hydroxylase, 3β hydroxysteroid dehydrogenase
  • Treat with corticosteroids or surgical excision of testes
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