Testis & epididymis
Germ cell tumors

Topic Completed: 1 August 2017

Minor changes: 9 September 2020

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PubMed Search: Chondrosarcoma testis

Jennifer Gordetsky, M.D.
Page views in 2020: 488
Page views in 2021 to date: 15
Cite this page: Gordetsky J. Chondrosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testischondrosarcoma.html. Accessed January 17th, 2021.
Definition / general
  • Malignant extraskeletal cartilage forming tumor arising from germ cell tumor (teratoma)
  • Young men with germ cell tumors that have a component of teratoma
  • Age range 19 - 40 years
  • Testis, retroperitoneum
  • Malignant transformation of cartilaginous component of teratoma
Radiology description
Radiology images

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MR image

CT scan

Prognostic factors
  • Strongest predictors of long survival are stage at presentation and feasibility to perform radical excision (Int J Surg Pathol 2011;19:321)
  • Secondary malignant component within a germ cell tumor rarely occurs and overall has a poor prognosis
Case reports
  • Surgical excision if feasible
  • Less sensitive to chemotherapy
Gross description
  • Gray to tan, firm, lobulated mass
Microscopic (histologic) description
  • Tumor cells produce cartilaginous matrix; either well, moderate or poorly differentiated
  • Well differentiated lesions are less cellular with few binucleated cells and mild to moderate atypia
  • Tend to have a lobulated architecture with abundant cartilaginous matrix separated by narrow fibrovascular bands
Molecular / cytogenetics description
  • Somatic type malignancies that develop in germ cell tumors tend to have the same genetic alterations, detectable by FISH and loss of heterozygosity studies, as in the corresponding teratoma
  • 12p overexpression and i(12p) has been reported (Am J Surg Pathol 2012;36:1849, Am J Surg Pathol 1993;17:738)
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