Testis & epididymis
Nonneoplastic lesions
Endometriosis-like lesion
Author: Swapnil U. Rane, M.D.
Topic Completed: 1 March 2015
Minor changes: 9 September 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed search: Endometriosis-like lesion
Table of Contents
Sites | Etiology and Pathophysiology | Clinical features | Case reports | Treatment | Gross description | Microscopic (histologic) description | ImmunohistochemistryCite this page: Rane S. Endometriosis-like lesion. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testisepidmisc.html. Accessed January 18th, 2021.
Sites
- Epididymis, prostate
Etiology and Pathophysiology
- Arises within remnants of Müllerian ducts (prostatic utricle and appendix testis)
- Most cases have been associated with estrogen therapy for prostrate carcinoma
- May arise in setting of chromosomal abnormalities affecting Müllerian inhibitory substance / MIS gene, in abnormalities of MIS secretion, gonadal dysgenesis and renal dysgenesis associated with abnormalities of Müllerian duct
Clinical features
- Usually incidental finding
Case reports
- 27 year old man with cystic endometriosis of epididymis (Urology 2006;68:203)
- 69 year old man with paratesticular endometriosis (Pathol Res Pract 2012;208:59)
Treatment
- Excision is curative
Gross description
- Small, single to multiple, unilocular or multilocular hemorrhagic cysts within epididymis, paratesticular region or rarely in testis
Microscopic (histologic) description
- A true cyst lined by cuboidal to columnar epithelium with hemosiderin laden macrophages in stroma
- Lumen contains hemorrhagic fluid
- Endometrial stroma may not be conspicuous but is usually present
