Testis & epididymis



Topic Completed: 1 August 2012

Minor changes: 8 September 2020

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PubMed Search: Hypospermatogenesis [title] infertility

Turki Al-Hussain, M.D.
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Cite this page: Al-Hussain T. Hypospermatogenesis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testishyposperm.html. Accessed November 27th, 2021.
Definition / general
  • All stages of spermatogenesis present but reduced to a varying degree
  • Includes the mixed pattern with some tubules showing Sertoli cells only or hyaline sclerosis with others tubules containing complete spermatogenesis
  • Mild if changes in occasional tubules; severe if significant reductions in all tubules, moderate in between
  • Often is thickening of tunica propria, interstitial fibrosis, tubular sclerosis, germ cell disorganization and sloughing into lumina
  • Many causes of infertility induce hypospermatogenesis, such as diabetes mellitus, toxins, excess heat, varicocele, hypothyroidism, irradiation and others
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