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Klinefelter syndrome


Turki Al-Hussain, M.D.

Topic Completed: 1 September 2012

Revised: 11 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Klinefelter syndrome [title] infertility

Turki Al-Hussain, M.D.
Page views in 2019: 1,678
Page views in 2020 to date: 640
Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Electron microscopy description
Cite this page: Al-Hussain T. Klinefelter syndrome. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testisklinefelter.html. Accessed April 8th, 2020.
Definition / general
  • 47XXY, reduced body and pubic hair, gynecomastia in 40 - 80%, high FSH, variable LH
  • Increased risk of breast cancer and extragonadal germ cell tumor
Gross description
  • Small, firm testes
Microscopic (histologic) description
  • Reduced number of intratubular germ cells, some tubules are Sertoli cell only
  • Also tubular sclerosis, Leydig cell nodules (appear hyperplastic due to tubular atrophy), focal spermatogenesis rarely seen
Microscopic (histologic) images

Images hosted on other servers:

Small hyalinized seminiferous tubules

Atrophy of seminiferous tubules

Hyalinized seminiferous tubules

Electron microscopy description
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