Testis & epididymis

Other tumors


Topic Completed: 1 October 2013

Minor changes: 31 December 2020

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PubMed Search: Testicular lymphoma [title]

Jennifer Gordetsky, M.D.
Page views in 2020: 2,949
Page views in 2021 to date: 2,775
Cite this page: Gordetsky J. Lymphoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testislymphoma.html. Accessed October 23rd, 2021.
Definition / general
  • Either primary or secondary involvement of testis by malignant / clonal lymphocytes
  • Almost always diffuse large B cell lymphoma
  • Also anaplastic lymphoma, Burkitt lymphoma, Hodgkin lymphoma, peripheral T cell lymphoma, follicular lymphoma
  • ~5% of testicular malignancies
  • Most common malignant testicular neoplasm in men over 60 years although can occur at any age (range 16 to 91 years, median age 67) (Clin Oncol (R Coll Radiol) 2012;24:358)
Clinical features
  • Painless testicular mass
  • Bilateral testicular involvement in up to 35% of cases; often spreads to CNS
Radiology description
  • Gray scale and color Doppler ultrasound findings include diffuse testicular infiltration / enlargement with hypervascularity or multifocal areas of hypoechoic, solid and hypervascular nodules within testes (Ultrasound Q 2013;29:247)
Prognostic factors
  • Better prognosis if testis involvement is primary site (60% 5 year survival vs. 17% for disseminated disease / other stages) and unilateral
Case reports
  • Orchiectomy and chemotherapy
Gross description
  • White tan pink, fleshy, resembles seminoma, often extratesticular involvement
Gross images

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Diffuse large B cell lymphoma

Microscopic (histologic) description
  • Splaying apart but relative sparing of tubules by lymphoma cells
  • Malignant cells are pleomorphic and noncohesive with large irregular nuclei and prominent nucleoli
  • May have vascular invasion and sclerosis of seminiferous tubules
  • No intratubular germ cell neoplasia
Microscopic (histologic) images

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Diffuse large B cell lymphoma

Peripheral T cell lymphoma

Positive stains
  • LCA / CD45
  • Other results dependent on lymphoma subtype
Negative stains
Differential diagnosis
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