Testis & epididymis
Germ cell tumors

Topic Completed: 1 January 2013

Minor changes: 9 September 2020

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PubMed Search: PNET testis

Turki Al-Hussain, M.D.
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Cite this page: Al-Hussain T. PNET. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testispnet.html. Accessed January 20th, 2021.
Definition / general
  • Primitive NEuroectodermal Tumor / Ewing sarcoma
  • Frequent "nongerm cell" tumor in patients with testicular germ cell tumors (Mod Pathol 2010;23:972)
  • Composed entirely of immature neural tissue
  • Considered a monodermal teratoma
  • Often fatal if metastases present (extratesticular), longer survival if neuroblastoma-like metastases
  • May arise in germ cell tumors and be testicular, extratesticular or both (Am J Surg Pathol 1997;21:896)
Case reports
Gross description
  • Grayish white, necrotic
Microscopic (histologic) description
  • Small cells with minimal cytoplasm in sheets, tubules, rosettes, pseudorosettes, medullary tubules and focally forming glia; overt overgrowth over immature teratoma by these cells
Positive stains
Electron microscopy description
  • Neurosecretory granules
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