Testis & epididymis


Infantile Sertoli cell proliferation

Topic Completed: 1 November 2013

Minor changes: 12 April 2021

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PubMed Search: sertoli cell tumor infantile testis

Swapnil U. Rane, M.D.
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Cite this page: Rane S. Infantile Sertoli cell proliferation. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testissertoliinfantile.html. Accessed December 3rd, 2021.
Definition / general
  • Intratubular Sertoli cell proliferations (ISCP) in infantile testis
  • May actually be discovered later in childhood
  • Strongly associated with Peutz-Jeghers syndrome
  • Occur in normally descended testis
  • Exact cause or molecular event is unknown
Clinical features
  • Commonly presents as gynecomastia in a young child (N Engl J Med 1991;324:317)
  • Testicular examination may reveal palpable nodules
  • May involve both testis simultaneously or sequentially
Radiology description
  • Ultrasound reveals small, multiple, bilateral hyperechoic images corresponding to numerous foci of ISCP
Prognostic factors
  • Traditionally, orchidectomy but no treatment may be recommended for isolated Sertoli cell proliferations
Gross description
  • Multiple yellowish white nodules on cross section; may be microscopic
Microscopic (histologic) description
  • Solid cords filled with proliferating Sertoli cells with thickened basement membranes with invaginations
  • Must exclude Sertoli cell tumor NOS or large cell calcifying Sertoli cell tumor
  • Anti-Müllerian hormone (strong), Inhibin α
  • Thickened basement membrane shows strong PAS+
Differential diagnosis
  • Large cell calcifying Sertoli cell tumor
    • Sertoli cell proliferation beyond the confines of the seminiferous tubules
    • Polygonal cells with abundant eosinophilic cytoplasm
    • Relatively large nuclei with prominent nucleoli
    • Myxoid to fibrous stroma with scattered, large, irregularly shaped islands of calcification
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