Testis & epididymis
Development
Testotoxicosis
Author: Turki Al-Hussain, M.D.
Topic Completed: 1 August 2012
Minor changes: 9 September 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: Testotoxicosis
Cite this page: Al-Hussain T. Testotoxicosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testistestotox.html. Accessed January 20th, 2021.
Definition / general
- Form of male sexual precocity with active Leydig cell differentiation and premature onset of spermatogenesis without pituitary gonadotropin stimulation (Arch Pathol Lab Med 1985;109:990)
- Due to apparent inherited intratesticular defect
Microscopic (histologic) description
- Leydig cells appear fully differentiated
- No Reinke crystals
- Germ cells at all stages of spermatogenesis present but with disordered maturation
- Structural abnormalities in spermatids
