Thyroid gland
Lithium thyroiditis

Topic Completed: 1 March 2009

Minor changes: 15 March 2019

Copyright: 2003-2017,, Inc.

PubMed Search: lithium thyroiditis

Shahid Islam, M.D., Ph.D.
Page views in 2019: 301
Page views in 2020 to date: 147
Cite this page: Islam S. Lithium thyroiditis. website. Accessed August 12th, 2020.
Definition / general
  • Lithium directly damages thyroid follicular cells, which releases thyroglobulin, which may be hydrolyzed to thyroxine, causing hyperthyroidism
Case reports
Microscopic (histologic) description
  • Small follicles with atrophy and minimal colloid; follicles contain desquamated follicular cells, macrophages and multinucleated giant cells; some giant cells contain birefringent calcium oxalate crystals (J Clin Pathol 1995;48:582)
Microscopic (histologic) images

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Case of the Week #139

Differential diagnosis
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