Thyroid gland
Papillary thyroid carcinoma
Rare variants

Topic Completed: 1 March 2009

Minor changes: 13 October 2020

Copyright: 2003-2020,, Inc.

PubMed Search: nodular fasciitis-like stroma papillary carcinoma

Shahid Islam, M.D., Ph.D.
Page views in 2019: 594
Page views in 2020 to date: 604
Cite this page: Islam S. Fibromatosis/fasciitis-like. website. Accessed December 5th, 2020.
Definition / general
  • Papillary carcinoma with prominent stromal reaction (but not the features of diffuse sclerosing variant)
  • Rare, first described in 1991 (Am J Clin Pathol 1991;95:309)
  • Similar behavior as classic papillary carcinoma; at presentation, 25% have nodal metastases, 13% have metastases to surrounding structures, no distant metastases (J Laryngol Otol 2006;120:338)
  • Stroma may be reactive (Histopathology 1992;21:577)
Case reports
Microscopic (histologic) description
  • Exuberant proliferation of fibroblasts / myofibroblasts with short fascicles and mucoid matrix, collagen and extravasated red blood cells, resembling fibromatosis or nodular fasciitis
  • Malignant epithelial component grows in narrow tubules, clustered glands or solid sheets, with variable squamous differentiation and papillae, has classic papillary nuclear features, but may be obscured by prominent stroma (Endocr Pathol 2002;13:219)
Microscopic (histologic) images

AFIP images

Nodular fasciitis-like stroma

Cytology description
Negative stains
Electron microscopy description
  • Myofibroblastic features
Differential diagnosis
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