Thyroid & parathyroid

Hyperplasia / goiter

Solitary papillary hyperplastic nodule

Topic Completed: 1 March 2009

Minor changes: 17 September 2020

Copyright: 2003-2021,, Inc.

PubMed Search: solitary papillary hyperplastic nodule

Shahid Islam, M.D., Ph.D.
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Cite this page: Islam S. Solitary papillary hyperplastic nodule. website. Accessed December 3rd, 2021.
  • Frequently occurs in children and teenagers
Gross description
  • Encapsulated, tan-brown nodules replace entire thyroid lobe, often central cystic change with brown hemorrhagic fluid
Microscopic (histologic) description
  • Well circumscribed and encapsulated nodules with central cystic and degenerative changes, prominent papillae with edematous stalks and occasional prominent vessels, lining cells have abundant cytoplasm and round nuclei, occasional prominent nucleoli, nuclear grooves or psammoma bodies, calcification
  • No intranuclear inclusions or well defined nuclear changes of papillary carcinoma
Cytology description
  • Pediatric solitary papillary hyperplastic nodules have broad flat sheets and 3D clusters, short nonbranching papillae with transgressing vessels, mild to moderate nuclear pleomorphism and nuclear atypia, occasional nuclear grooves
  • Unlike papillary thyroid carcinoma, has fire flares, short nonbranching papillae, watery and inspissated colloid
  • No intranuclear inclusions
  • Negative for CK19 (Arch Pathol Lab Med 2001;125:1575)
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