Thyroid & parathyroid

Other thyroid malignancies


Last author update: 1 July 2015
Last staff update: 18 August 2023

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PubMed Search: Teratoma thyroid

Note: Teratoma is described in detail at Mediastinum - Teratoma-cystic; this topic only describes features specific to the thyroid gland

Sheren Younes, M.D., Ph.D.
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Cite this page: Younes S. Teratoma. website. Accessed April 14th, 2024.
Definition / general
  • Teratoma is a germ cell tumor characterized by the presence of 3 germ cell layers: ectoderm, endoderm and mesoderm
  • Common in newborns and infants (usually benign), rare in adolescence, usually malignant in adults (Cancer 2000;88:1149)
Clinical features
  • Thyroid mass, usually normal thyroid function
Radiology images

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Heterogeneously hypoechoic nodule

Large cystic fat-containing mass

Case reports
Gross description
  • Usually cystic
Gross images

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Well encapsulated, mixed solid and cystic mass

Lymph node involvement

Microscopic (histologic) description
  • Neuro / ectodermal tissue: squamous epithelium, glial tissue
  • Endodermal tissue: GI epithelium, thyroid and salivary glands
  • Mesodermal tissue: bone and cartilage
  • Presence of immature tissue or neuroepithelium makes it a malignant immature teratoma (Am J Surg Pathol 2005;29:700)
Microscopic (histologic) images

AFIP images

Newborn infant

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Benign thyroid teratoma


Primitive neuroepithelial cells

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