Mucoepidermoid carcinoma

Larynx, hypopharynx & trachea
Salivary carcinoma
Mucoepidermoid carcinoma

Author: Adriana Handra-Luca, M.D.

Topic Completed: 1 October 2012

Minor changes: 26 November 2019

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PubMed Search: Mucoepidermoid carcinoma trachea

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Table of Contents

Cite this page: Handra-Luca A. Mucoepidermoid carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/tracheamucoepidermoid.html. Accessed May 29th, 2020.

Definition / general

Usually low grade lesion with squamous cells without atypia in desmoplastic stroma

Clinical features

Usually children with a luminal polyp, possibly with bronchus extension
May occur in patients with tracheobronchopathia osteochondroplastica
Symptoms: dyspnea, stridor

Case reports

9 year old boy with dyspnea and diaphoresis (Interact Cardiovasc Thorac Surg 2012;15:311)
11 year old girl with dedifferentiated tumor (Histopathology 2009;55:472)
22 year old woman with exertional dyspnea and stridor (Pneumologia 2011;60:164)
51 year old man with tracheobronchopathia osteochondroplastica (Chirurg 1995;66:231)
78 year old woman with oncocytic tumor (Arch Pathol Lab Med 1999;123:635)

Treatment

Resection

Microscopic (histologic) description

Low grade lesion with foci of squamous differentiation without atypia in desmoplastic stroma
Prominent vascular component
No marked atypia, no necrosis, no mitotic activity, no angiolymphatic invasion, may be dedifferentiated

Microscopic (histologic) images

Images hosted on other servers:

Oncocytic tumor:
simple cysts, oncocytes and
antimitochondrial antibody

Positive stains

Keratin (entire tumor)
Oncocytic tumor: PTAH and antimitochondrial antibody in oncocytes

Negative stains

Neuroendocrine markers, Congo red

Differential diagnosis

Carcinoid tumor