Larynx, hypopharynx & trachea
Other malignancies
Mucoepidermoid carcinoma

Topic Completed: 1 October 2012

Minor changes: 3 March 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Mucoepidermoid carcinoma trachea

Adriana Handra-Luca, M.D.
Page views in 2020: 359
Page views in 2021 to date: 105
Cite this page: Handra-Luca A. Mucoepidermoid carcinoma. website. Accessed March 3rd, 2021.
Definition / general
  • Usually low grade lesion with squamous cells without atypia in desmoplastic stroma
Clinical features
  • Usually children with a luminal polyp, possibly with bronchus extension
  • May occur in patients with tracheobronchopathia osteochondroplastica
  • Symptoms: dyspnea, stridor
Case reports
  • Resection
Microscopic (histologic) description
  • Low grade lesion with foci of squamous differentiation without atypia in desmoplastic stroma
  • Prominent vascular component
  • No marked atypia, no necrosis, no mitotic activity, no angiolymphatic invasion, may be dedifferentiated
Positive stains
  • Keratin (entire tumor)
  • Oncocytic tumor: PTAH and antimitochondrial antibody in oncocytes
Negative stains
Differential diagnosis
  • Carcinoid tumor
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