Papilloma / papillomatosis

Topic Completed: 1 October 2012

Minor changes: 26 November 2019

Copyright: 2002-2017,, Inc.

PubMed Search: Trachea papilloma papillomatosis [title]

Adriana Handra-Luca, M.D.
Page views in 2019: 1,950
Page views in 2020 to date: 611
Cite this page: Handra-Luca A. Papilloma / papillomatosis. website. Accessed May 30th, 2020.
Definition / general
Clinical features
  • Juvenile and adult onset
  • Symptoms: cough, hemophtysis
  • May disappear spontaneously
  • May occur in patient with primary biliary cirrhosis, Cowden disease, tuberculosis
  • Cases associated with laryngeal lesions have low incidence of malignant transformation
  • Cases limited to trachea and bronchi usually begin in adults, have higher incidence of malignant transformation
  • Tracheotomy is associated with progression of laryngeal papilloma into trachea (Zhonghua Er Bi Yan Hou Ke Za Zhi 2000;35:384)
Case reports
  • HPV vaccine (to prevent); medical therapy, multiple surgery if recurrence
Microscopic (histologic) description
  • Usually benign squamous, intermediate and ciliated cells overlying fibrovascular stroma
  • Invasive tumor may have intracystic papillary structures, atypical invasive epithelium
Differential diagnosis
  • Oat cell carcinoma: looks similar at bronchoscopy
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