Transfusion medicine
Transfusion reactions & complications
Hemoglobinopathy (apparent)
Author: Huy P. Pham, M.D., M.P.H.
Last author update: 1 September 2011
Last staff update: 19 February 2021
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Transfusion side effects hemoglobinopathy apparent
Cite this page: Pham H. Hemoglobinopathy (apparent). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/transfusionmedhemoglobinopathy.html. Accessed May 29th, 2023.
Definition / general
- Due to donor blood with a hemoglobinopathy, most commonly hemoglobin C
- Abnormal hemoglobin ranges from 1 - 14% of recipient hemoglobin; recipient often has received multiple transfusions (Arch Pathol Lab Med 2006;130:1830)
- Important to identify to avoid unnecessary testing and treatment; must also notify the donor
- Important to send untransfused sample to test for hemoglobinopathy or red cell enzymatic defects
- Detection of hemoglobinopathies may rarely be suppressed by transfusions (Arch Pathol Lab Med 2005;129:e107)
- See also transfusion associated microchimerism
Case reports
- Hemoglobin C (Arch Pathol Lab Med 1999;123:642)
