Transfusion medicine

Transfusion reactions & complications

Hemoglobinopathy (apparent)

Last author update: 1 September 2011
Last staff update: 19 February 2021

Copyright: 2002-2023,, Inc.

PubMed Search: Transfusion side effects hemoglobinopathy apparent

Huy P. Pham, M.D., M.P.H.
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Cite this page: Pham H. Hemoglobinopathy (apparent). website. Accessed May 29th, 2023.
Definition / general
  • Due to donor blood with a hemoglobinopathy, most commonly hemoglobin C
  • Abnormal hemoglobin ranges from 1 - 14% of recipient hemoglobin; recipient often has received multiple transfusions (Arch Pathol Lab Med 2006;130:1830)
  • Important to identify to avoid unnecessary testing and treatment; must also notify the donor
  • Important to send untransfused sample to test for hemoglobinopathy or red cell enzymatic defects
  • Detection of hemoglobinopathies may rarely be suppressed by transfusions (Arch Pathol Lab Med 2005;129:e107)
  • See also transfusion associated microchimerism
Case reports
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