Transfusion medicine
Transfusion reactions & complications
Immune system modulation
Author: Huy Phu Pham, M.D., M.P.H.
Topic Completed: 1 September 2011
Minor changes: 16 July 2020
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Transfusion related immunomodulation (Review[ptyp] "loattrfree full text"[sb])
Table of Contents
Definition / generalCite this page: Pham HP Immune system modulation. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/transfusionmedtrim.html. Accessed April 19th, 2021.
Definition / general
- Transfusion is "liquid allogeneic transplant," causing changes to immunologic profile of recipient (Arch Pathol Lab Med 2007;131:708)
- Termed "transfusion related immunomedulation" (TRIM)
Established and proposed TRIM:
- Humoral immunity: RBC alloimmunization
- Cellular immunity:
- Decrease in renal allograft rejection (Hum Immunol 2002;63:902)
- Improvement in some autoimmune diseases, such as Crohn's disease (Colon Rectum 1989;32:749)
- Decrease in repetitive spontaneous abortions
- Increase in tumor recurrence
- Increase in postoperative infections (Crit Care Med 2002;30:2249) and overall mortality (JAMA 2002;288:1499)
