Topic Completed: 1 December 2011

Minor changes: 5 August 2020

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PubMed search: atrophy [title] uterus

Nat Pernick, M.D.
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Cite this page: Pernick N. Atrophy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uterusatrophy.html. Accessed August 8th, 2020.
Definition / general
  • Normal in prepubertal girls, perimenopausal or menopausal women
Clinical features
Gross images

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Endometrial atrophy

Microscopic (histologic) description
  • Low cuboidal or columnar epithelium with no mitotic figures
  • Glands usually tubular or cystic, may be closely packed
  • Stroma appears inactive with variable collagenization and minimal mitotic activity
Microscopic (histologic) images

AFIP images


Simple atrophy: this hysterectomy specimen from a postmenopausal woman
contains a thin endometrium with only a few residual glands surrounded by an atrophic,
somewhat fibrotic stroma; the junction between endometrium and myometrium
is not sharply defined, and the underlying myometrium also appears atrophic


Cystic atrophy: this photomicrograph shows most of the specimen
obtained at curettage from a postmenopausal woman who presented with
vaginal bleeding; the glands vary from small to cystically dilated, but all
are lined by a single layer of epithelial cells that are cuboidal to flattened


Histopathology Endometrium - Senile atrophySenile atrophy

Differential diagnosis
  • Basalis endometrium, lower uterine segment, endometrial lining of submucous myoma, polyp, progesterone effect
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