Smooth muscle tumors

Benign metastasizing leiomyoma

Last author update: 1 August 2011
Last staff update: 20 January 2021

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PubMed search: benign metastasizing leiomyoma uterus

Related topics: leiomyoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Benign metastasizing leiomyoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uterusleiomyomabenignmet.html. Accessed December 9th, 2022.
Definition / general
  • May be a biologically distinct subset of leiomyoma, based on cytogenetic abnormalities (see below)
  • Leiomyoma extends into vessels, migrates to lung or lymph nodes
  • Original tumor must clearly be benign and sampled adequately
  • Must rule out primary smooth muscle tumor of GI tract, retroperitoneum or other areas
  • "Metastasis" may respond to hormonal treatment; may occur years after uterine resection
  • Symptoms: none, bleeding, frequency, pain or infertility
  • Associated with spontaneous abortion, postpartum hemorrhage
Case reports
Microscopic (histologic) description
  • Benign smooth muscle cells; no atypia, no mitotic figures, no necrosis
Microscopic (histologic) images

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Uterine and lung tumors

Uterine and lung tumors

Benign metastasizing
leiomyoma with coexisting
primary lung carcinoma

Positive stains
Molecular / cytogenetics description
Differential diagnosis
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