Uterus
Smooth muscle tumors
Epithelioid leiomyoma
Author: Nat Pernick, M.D.
Topic Completed: 1 August 2011
Minor changes: 12 August 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed search: epithelioid leiomyoma uterus
Related topics: leiomyoma
Table of Contents
Definition / general | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy description | Differential diagnosisCite this page: Pernick N. Epithelioid leiomyoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uterusleiomyomaepithelioid.html. Accessed January 18th, 2021.
Definition / general
- Also known as clear cell leiomyoma, leiomyomblastoma (which may mimic smooth muscle cells of fetal uterus)
Microscopic (histologic) description
- Round epithelioid, rhabdoid and large vacuolated cells intermingled with spindled cells
- Clear or eosinophilic cytoplasm; no prominent nuclear atypia
- No tumor cell necrosis; no mitotic figures (Histopathology 2003;42:379)
- May have transition to typical smooth muscle
Microscopic (histologic) images
Images hosted on other servers:
Various images
Positive stains
Electron microscopy description
- Various amounts of intermediate filaments; intermediate filaments and bundles of thin filaments without dense bodies often intermingled and occasionally form distinctive complexes with many irregular dense body-like structures and crystalloid bodies; also abundant mitochondria, some rough endoplasmic reticulum and free ribosomes (Histopathology 2003;42:379)
Differential diagnosis
- PEComa: HMB45+, CD1a+ (Ann Diagn Pathol 2008;12:401)
- Carcinoma: has atypia, mitotic figures, tumor cell necrosis
