Smooth muscle tumors
Epithelioid leiomyoma

Topic Completed: 1 August 2011

Minor changes: 12 August 2020

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PubMed search: epithelioid leiomyoma uterus

Related topics: leiomyoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Epithelioid leiomyoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uterusleiomyomaepithelioid.html. Accessed January 18th, 2021.
Definition / general
  • Also known as clear cell leiomyoma, leiomyomblastoma (which may mimic smooth muscle cells of fetal uterus)
Microscopic (histologic) description
  • Round epithelioid, rhabdoid and large vacuolated cells intermingled with spindled cells
  • Clear or eosinophilic cytoplasm; no prominent nuclear atypia
  • No tumor cell necrosis; no mitotic figures (Histopathology 2003;42:379)
  • May have transition to typical smooth muscle
Microscopic (histologic) images

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Various images

Positive stains
Negative stains
Electron microscopy description
  • Various amounts of intermediate filaments; intermediate filaments and bundles of thin filaments without dense bodies often intermingled and occasionally form distinctive complexes with many irregular dense body-like structures and crystalloid bodies; also abundant mitochondria, some rough endoplasmic reticulum and free ribosomes (Histopathology 2003;42:379)
Differential diagnosis
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