Uterus
Smooth muscle tumors
Lipoleiomyoma
Author: Nat Pernick, M.D.
Topic Completed: 1 August 2011
Minor changes: 12 August 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed search: lipoleiomyoma [title] uterus
Related topics: leiomyoma
Table of Contents
Definition / general | Case reports | Gross images | Microscopic (histologic) images | Positive stainsCite this page: Pernick N. Lipoleiomyoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uterusleiomyomalipo.html. Accessed January 18th, 2021.
Definition / general
- 2% of all leiomyomas; combination of leiomyoma and mature adipocytes with benign behavior (Int J Gynecol Pathol 2006;25:239)
- Also includes neoplasms composed entirely of mature adipocytes
- May be due to adipose metaplasia in leiomyomas; does not appear to be degenerative, since adipose tissue has low proliferative activity by Ki67 staining
- May give rise to liposarcoma (Am J Surg Pathol 2011;35:221)
Case reports
- 50 year old woman with 8.5 cm tumor (J Midlife Health 2010;1:86)
- 57 year old woman with plexiform tumor with amyloid stroma (Arch Gynecol Obstet 2006;274:117)
- Intravascular uterine tumors (Hum Pathol 1989;20:252)
Gross images
Images hosted on other servers:
Pale yellow to bright yellow appearance
Intramural yellow tumor
Microscopic (histologic) images
Images hosted on other servers:
Various images
Positive stains
- Adipose component: Ki67 (low), ER, PR, S100, vimentin (Appl Immunohistochem Mol Morphol 2015;23:e1)
- Smooth muscle component: Ki67 (low), ER, PR, vimentin, desmin, alpha smooth muscle actin
