Uterus
Smooth muscle tumors
Leiomyoma with bizarre nuclei
Author: Nat Pernick, M.D.
Topic Completed: 9 February 2017
Minor changes: 12 August 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed search: symplastic [title] OR atypical [title] leiomyoma
Related topics: leiomyoma
Table of Contents
Definition / general | Terminology | Case reports | Gross images | Microscopic (histologic) images | Positive stains | Additional referencesCite this page: Pernick N. Leiomyoma with bizarre nuclei. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uterusleiomyomasymplastic.html. Accessed January 17th, 2021.
Definition / general
- Contains bizarre multinucleated tumor cells (moderate / severe atypia), less than 10 mitotic figures/10 HPF and NO tumor cell necrosis
- Associated with progestin use
- Benign behavior (Am J Surg Pathol 1997;21:1261), but rarely leiomyosarcomas may arise from them (Mod Pathol 2009;22:1303)
Terminology
- Previously called symplastic or atypical leiomyoma
Case reports
- 38 year old woman with morcellated myomectomy specimen (Case of the Week #352)
Gross images
Images hosted on other servers:
Bizarre leiomyoma
Microscopic (histologic) images
Case #352
Various images
Various images
Images hosted on other servers:
Various atypical leiomyoma images
Positive stains
- p16 (85%), P53 (39%, Int J Gynecol Pathol 2009;28:529)
Additional references
