Smooth muscle tumors
Leiomyoma with bizarre nuclei

Topic Completed: 9 February 2017

Minor changes: 12 August 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed search: symplastic [title] OR atypical [title] leiomyoma

Related topics: leiomyoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Leiomyoma with bizarre nuclei. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uterusleiomyomasymplastic.html. Accessed January 17th, 2021.
Definition / general
  • Contains bizarre multinucleated tumor cells (moderate / severe atypia), less than 10 mitotic figures/10 HPF and NO tumor cell necrosis
  • Associated with progestin use
  • Benign behavior (Am J Surg Pathol 1997;21:1261), but rarely leiomyosarcomas may arise from them (Mod Pathol 2009;22:1303)
  • Previously called symplastic or atypical leiomyoma
Case reports
Gross images

Images hosted on other servers:

Bizarre leiomyoma

Microscopic (histologic) images

Case #352

Various images

Various images

Images hosted on other servers:

Various atypical leiomyoma images

Positive stains
Additional references
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