Vulva, vagina & female urethra

Topic Completed: 1 March 2014

Minor changes: 2 June 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Angiomyofibroblastoma vagina

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Cite this page: Mansouri J. Angiomyofibroblastoma. website. Accessed August 8th, 2020.
Definition / general
  • Vagina (10 - 15% of cases)
  • Vulva (majority of cases)
Clinical features
  • Presents as slowly enlarging and painless mass
  • May be mistaken for Bartholin cyst or genital prolapse
Prognostic factors
  • Benign, rarely recurs when marginally excised
  • Important to rule out angiomyxomatous or sarcomatous foci in rare cases
Case reports
  • Local excision
Gross description
  • Well circumscribed, soft, 0.5 to 12.0 cm, without necrosis
  • May have pseudocapsule
Microscopic (histologic) description
  • Circumscribed tumor with alternating hypercellular and hypocellular areas, spindle cells and plump stromal cells with eosinophilic cytoplasm that aggregate around small blood vessels
  • May have binucleated or multinucleated cells
  • Mast cells common
  • Minimal stromal mucin, rare / no red blood cell extravasation, no atypia
  • Rare / no mitotic figures
Microscopic (histologic) images

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Zones of hypo and hypercellularity

Round to oval, plump spindle cells

Cytology description
  • Tumor cells with epithelioid or plasmacytoid features, may be binucleated or multinucleated
Positive stains
Negative stains
Electron microscopy description
  • Well developed rough endoplasmic reticulum, Golgi apparatus, intermediate filaments, pinocytotic vesicles
Differential diagnosis
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