Vulva, vagina & female urethra


Staging-female urethra

Last staff update: 23 December 2022 (update in progress)

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PubMed Search: Female urethra staging

Debra L. Zynger, M.D.
Page views in 2022: 184
Page views in 2023 to date: 99
Cite this page: Zynger DL. Staging-female urethra. website. Accessed May 30th, 2023.
Definition / general
  • All carcinomas of the female urethra are covered by this staging system
Essential features
  • AJCC 7th edition staging was sunset on December 31, 2017; as of January 1, 2018, use of the 8th edition is mandatory
ICD coding
  • ICD-10: C68.0 - malignant neoplasm of urethra
Primary tumor (pT)
  • pTX: cannot be assessed
  • pT0: no evidence of primary tumor
  • pTa: noninvasive papillary carcinoma
  • pTis: carcinoma in situ
  • pT1: invasion of urethral subepithelial connective tissue
  • pT2: invasion of periurethral muscle
  • pT3: invasion of anterior vagina
  • pT4: invasion of adjacent organs (example: bladder wall)
Regional lymph nodes (pN)
  • pNX: cannot be assessed
  • pN0: no regional lymph node metastasis
  • pN1: metastasis in 1 regional lymph node
  • pN2: metastasis in greater than 1 regional lymph node

  • Regional lymph nodes include superficial / deep inguinal, perivesical, obturator, internal iliac / hypogastric, external iliac, presacral, sacral NOS, pelvic NOS
Distant metastasis (pM)
  • pM1: distant metastasis
  • y: preoperative radiotherapy or chemotherapy
  • r: recurrent tumor stage
AJCC prognostic stage groups
Stage 0a:  Ta  N0  M0
Stage 0is:  Tis  N0  M0
Stage I:  T1  N0  M0
Stage II:  T2  N0  M0
Stage III:  T3  N0  M0
 T1 - 3  N1  M0
Stage IV:  T4  N0 - 2  M0 - 1
 TX - 4  N2  M0 - 1
 TX - 4  NX - 2  M1
Registry data collection variables
  • Urothelial carcinoma grade (high / low)
  • Squamous cell / adenocarcinoma grade (1 - 3)
Histologic grade (G)
  • Urothelial carcinoma
    • LG: low grade
    • HG: high grade
  • Squamous cell / adenocarcinoma
    • GX: cannot be assessed
    • G1: well differentiated
    • G2: moderately differentiated
    • G3: poorly differentiated
Histopathologic type
  • Noninvasive urothelial carcinoma
  • Invasive urothelial carcinoma
    • Conventional urothelial carcinoma
    • Urothelial carcinoma variants
  • Squamous cell carcinoma
  • Adenocarcinoma (including those arising from periurethral glands)
  • Small cell carcinoma
Board review style question #1
A urothelial carcinoma of the female urethra at the deepest point of invasion involves the bladder wall. Which is the correct pT category?

  1. pT1
  2. pT2
  3. pT3
  4. pT4
Board review style answer #1
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