Vulva, vagina & female urethra

General

Staging-female urethra



Topic Completed: 3 January 2019

Minor changes: 11 June 2021

Copyright: 2019-2021, PathologyOutlines.com, Inc.

PubMed Search: urethra staging [title] female

Debra L. Zynger, M.D.
Page views in 2020: 111
Page views in 2021 to date: 132
Cite this page: Zynger D. Staging-female urethra. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/vulvaurethrastaging.html. Accessed October 15th, 2021.
Definition / general
  • All carcinomas of the female urethra are covered by this staging system
Essential features
  • AJCC 7th edition staging was sunset on December 31, 2017; as of January 1, 2018, use of the 8th edition is mandatory
ICD coding
  • ICD-10: C68.0 - malignant neoplasm of urethra
Primary tumor (pT)
  • pTX: cannot be assessed
  • pT0: no evidence of primary tumor
  • pTa: noninvasive papillary carcinoma
  • pTis: carcinoma in situ
  • pT1: invasion of urethral subepithelial connective tissue
  • pT2: invasion of periurethral muscle
  • pT3: invasion of anterior vagina
  • pT4: invasion of adjacent organs (example: bladder wall)
Regional lymph nodes (pN)
  • pNX: cannot be assessed
  • pN0: no regional lymph node metastasis
  • pN1: metastasis in 1 regional lymph node
  • pN2: metastasis in greater than 1 regional lymph node

Note:
  • Regional lymph nodes include superficial / deep inguinal, perivesical, obturator, internal iliac / hypogastric, external iliac, presacral, sacral NOS, pelvic NOS
Distant metastasis (pM)
  • pM1: distant metastasis
Prefixes
  • y: preoperative radiotherapy or chemotherapy
  • r: recurrent tumor stage
AJCC prognostic stage groups
  • Stage 0a:Ta N0 M0
  • Stage 0is:Tis N0 M0
  • Stage I:T1 N0 M0
  • Stage II:T2 N0 M0
  • Stage III:T3 N0 M0
  • T1 - 3 N1 M0
  • Stage IV:T4 N0 - 2 M0 - 1
  • TX - 4 N2 M0 - 1
  • TX - 4 NX - 2 M1

Registry data collection variables
  • Urothelial carcinoma grade (high / low)
  • Squamous cell / adenocarcinoma grade (1 - 3)
Histologic grade (G)
  • Urothelial carcinoma
    • LG: low grade
    • HG: high grade
  • Squamous cell / adenocarcinoma
    • GX: cannot be assessed
    • G1: well differentiated
    • G2: moderately differentiated
    • G3: poorly differentiated
Histopathologic type
  • Noninvasive urothelial carcinoma
  • Invasive urothelial carcinoma
    • Conventional urothelial carcinoma
    • Urothelial carcinoma variants
  • Squamous cell carcinoma
  • Adenocarcinoma (including those arising from periurethral glands)
  • Small cell carcinoma
Board review style question #1
A urothelial carcinoma of the female urethra at the deepest point of invasion involves the bladder wall. Which is the correct pT category?

  1. pT1
  2. pT2
  3. pT3
  4. pT4
Board review style answer #1
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