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Dr. Pernick's Curing Cancer Network



Copyright: 2021, PathologyOutlines.com, Inc.
Revised: 20 September 2021


General
  • This project of Dr. Pernick discusses the implementation of his strategic plan to substantially reduce cancer deaths. It is built on the management philosophy of PathologyOutlines.com to first determine your goals and then work towards them, even if they seem overly ambitious. We are more interested in reducing cancer deaths than doing things a certain way.
  • This project is independent of the PathologyOutlines.com textbook and its Editorial Board, and is not peer reviewed.
  • Click here to sign up for our monthly newsletter. You can also text CURINGCANCERNET (with no spaces) to 22828 to sign up.
References
Agree or disagree?
Every few months, we will post a provocative question and some of the responses relating to reducing cancer deaths.

September 2021 question:
  • Agree or disagree? It is important to have a strategic plan to substantially reduce annual U.S. cancer deaths, even if we don't know precisely how to do this.
  • Email your detailed response to Dr. Pernick at Nat@PathologyOutlines.com by 31 October 2021. He will reply to all serious responses and will post some of them, so also tell him how you want your name listed (full name, initials or anonymous).

View past questions / responses (click to expand)

July 2021 question:
  • We propose that pancreatic adenocarcinoma, NOS and other aggressive cancers can be successfully treated using large combinations of partially effective treatments directed against the tumor's malignant traits because the behavior of the whole is greater than the behavior of the sum of the parts, see Combinations Of Therapy to Substantially Reduce Cancer Deaths. Of course, this will require the development of new treatments against some of these traits.
  • Agree or disagree?
  • Email Dr. Pernick at Nat@PathologyOutlines.com with your opinion by 31 July 2021. He will reply to all serious responses and will post the best responses in August 2021, so also tell him how you want your name listed (full name, initials or anonymous).

July 2021 response:
  • Clinically successful combinations of cancer therapies are often pharmacologically additive. When combining therapies that are individually highly effective, additivity can be the basis for spectacular clinical benefits, such as the RCHOP regimen producing high cure rates in diffuse large B cell lymphoma. One implication of drug additivity is that 'adding zeros' makes zero. This suggests that developing successful combination therapies for aggressive cancers will first require the development of more therapies that have good individual anti-tumor activity in these diseases. The standard for efficacy is not unattainably high. For example, before combination therapy became standard for pediatric acute lymphocytic leukemia, single therapies could produce temporary remissions, around 3 to 6 months in duration, in a quarter of the patients (these 'remissions' meant multiple log-kills resulting in the absence of detectable disease, and should not be confused for temporarily stable disease or partial response). These therapies went on to become the constituents of curative combination regimens.
    • By Adam Palmer, Ph.D., Assistant Professor of Pharmacology, UNC Chapel Hill
Grants
  • Grants related to our Strategic plan to reduce cancer deaths - deadline 30 September 2021
    We welcome your proposal (up to 500 words) to research one of the bulleted tasks discussed in our Strategic plan. Include CVs of principal investigators. Email Dr. Pernick at Nat@PathologyOutlines.com.
Tasks
Blog articles
Latest article:
All articles:
Videos

Strategic plan update (September 2021)

Strategic plan to substantially reduce cancer deaths (July 2021)


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