Skin - Nonmelanocytic tumors
Vascular tumors

Author: Christopher Hale, M.D. (see Authors page)

Revised: 6 October 2016, last major update July 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: angiosarcoma [title] skin

Cite this page: Angiosarcoma. website. Accessed October 24th, 2016.
Definition / General
  • Also called malignant hemangioendothelioma
  • Skin cases are in head and neck of elderly, not young patients, unless also associated with chronic lymphedema or radiotherapy (these lesions are often called lymphangiosarcomas)
  • Slow growing but highly aggressive with frequent recurrences that involve extensive areas of face and scalp
  • Metastasize to regional lymph nodes, lungs, other organs
Case Reports
Gross Description
  • Violet elevated nodules on flat lesion with ill defined margins
  • May be verrucoid
Gross Images
Images hosted on other servers:

Scalp, neck and breast lesions

Micro Description
  • Infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen
  • Intracytoplasmic vacuoles represent lumina
  • Also areas resembling Kaposi’s sarcoma and undifferentiated foci resembling melanoma or carcinoma
  • May have focal granular cell features
  • May extend into scalp aponeurosis
Micro Images
Images hosted on other servers:

Various images

Positive Stains
Negative Stains
Electron Microscopy Description
  • Features of endothelial cells
Molecular / Cytogenetics Description
  • Not diploid by flow cytometry
Differential Diagnosis