Table of ContentsDefinition / general | Clinical images | Microscopic (histologic) images | Positive stains | Differential diagnosis
Cite this page: Shankar, V. Kaposi sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuekaposi.html. Accessed March 23rd, 2018.
Definition / general
- Vascular proliferative disorder mediated by inflammatory cytokines and angiogenic growth factors in patients with HHV8 / Kaposi sarcoma associated herpesvirus infection, influenced by immune status
- May originate from cell type capable of undergoing lymphatic differentiation based on D2-40 staining, a lymphatic specific marker (Mod Pathol 2002;15:434)
- Usually limited to skin; may involve mucus membranes, visceral organs, lymph nodes
- HHV8 also positive in multicentric Castleman's disease, primary effusion lymphoma, some multiple myeloma
Microscopic (histologic) images