Soft tissue
Low / intermediate grade vascular tumors
Kaposi sarcoma

Author: Vijay Shankar, M.D.

Revised: 7 September 2018, last major update November 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed search: Kaposi sarcoma [title] soft tissue

Related topics: AIDS associated, Chronic, Lymphadenopathic, Transplant-associated

Cite this page: Shankar, V. Kaposi sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuekaposi.html. Accessed November 14th, 2018.
Definition / general
  • Vascular proliferative disorder mediated by inflammatory cytokines and angiogenic growth factors in patients with HHV8 / Kaposi sarcoma associated herpesvirus infection, influenced by immune status
  • May originate from cell type capable of undergoing lymphatic differentiation based on D2-40 staining, a lymphatic specific marker (Mod Pathol 2002;15:434)
  • Usually limited to skin; may involve mucus membranes, visceral organs, lymph nodes
  • HHV8 also positive in multicentric Castleman disease, primary effusion lymphoma, some multiple myeloma
Clinical images

Images hosted on PathOut server:

Contributed by Mark R. Wick, M.D.
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Mark R. Wick, M.D.

HHV8

Hyaline globules

Various images

Differential diagnosis