Table of ContentsDefinition / General | Clinical Images | Micro Images | Positive Stains | Differential Diagnosis
Cite this page: Kaposi sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuekaposi.html. Accessed December 11th, 2016.
Definition / General
- Vascular proliferative disorder mediated by inflammatory cytokines and angiogenic growth factors in patients with HHV8 / Kaposi sarcoma associated herpesvirus infection, influenced by immune status
- May originate from cell type capable of undergoing lymphatic differentiation based on D2-40 staining, a lymphatic specific marker (Mod Pathol 2002;15:434)
- Usually limited to skin; may involve mucus membranes, visceral organs, lymph nodes
- HHV8 also positive in multicentric Castleman's disease, primary effusion lymphoma, some multiple myeloma