Soft Tissue
Low / intermediate grade vascular tumors
Kaposi sarcoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 22 September 2016, last major update November 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: kaposi sarcoma [title] soft tissue

Related topics: AIDS associated, Chronic, Lymphadenopathic, Transplant-associated

Definition / General
  • Vascular proliferative disorder mediated by inflammatory cytokines and angiogenic growth factors in patients with HHV8 / Kaposi sarcoma associated herpesvirus infection, influenced by immune status
  • May originate from cell type capable of undergoing lymphatic differentiation based on D2-40 staining, a lymphatic specific marker (Mod Pathol 2002;15:434)
  • Usually limited to skin; may involve mucus membranes, visceral organs, lymph nodes
  • HHV8 also positive in multicentric Castleman's disease, primary effusion lymphoma, some multiple myeloma
Clinical Images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick

Micro Images
Images hosted on PathOut server:

HHV8, courtesy of Dr. Mark R. Wick

Hyaline globules, courtesy of Dr. Mark R. Wick

Courtesy of Dr. Mark R. Wick



Images hosted on other servers:

VEGFR3+ (fig C/D)

D2-40+

Differential Diagnosis