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Coagulation
Reviewers: Kendall Crookston, M.D., Ph.D.; Julie Gober-Wilcox, M.D.; Jeremy Parsons, M.D.; Lizabeth Rosenbaum, M.D. (see Reviewers page)
Revised: 10 April 2013, last major update April 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
Table of contents
General: primary references hemostasis-general normal hemostasis intrinsic pathway extrinsic pathway common pathway protein C/S thrombomodulin antithrombin fibrinolysis pathway contact system
Bleeding disorders: general laboratory approach
Acquired bleeding disorders: acute phase reaction acquired
dysfibrinogenemia acquired
von Willebrand disease amyloidosis bovine coagulation factor inhibitors DIC factor V inhibitor factor VIII inhibitor inhibitors in nonhemophilia patients factor IX inhibitor liver dysfunction lupus anticoagulants proteinuria Vitamin K deficiency/warfarin
Hereditary bleeding disorders: general algorithm for workup factor I (fibrinogen) deficiency factor II (prothrombin) deficiency factor V deficiency factor VII deficiency factor VIII deficiency (hemophilia A) factor IX deficiency (hemophilia B) factor X deficiency factor XI deficiency factor XII deficiency factor XIII deficiency high molecular weight kininogen deficiency prekallifrein deficiency von Willebrand disease
Therapy related coagulopathies: warfarin danaparoid heparin heparin-low molecular weight hirudin thrombolytic therapy
Acquired thrombophilia / hypercoagulopathies: general antiphospholipid antibodies heparin induced thrombocytopenia
Hereditary thrombophilia / hypercoagulopathies: general activated protein C resistance / Factor V Leiden antithrombin deficiency dysfibrinogenemia elevated coagulation factors heparin cofactor II deficiency hyperhomocysteinemia protein C deficiency protein S deficiency prothrombin gene mutation (G20210A) sickle cell disease
Coagulation laboratory tests: general quality assurance abnormal PT and PTT activated clotting time activated protein C resistance / Factor V Leiden anticardiolipin antibodies antiplasmin antithrombin bleeding time clot retraction cryoglobulin / cryofibrinogen D-dimer dabigatran ecarin clotting time factor assays factor I (fibrinogen) assay factor V Leiden factor VII assay factor VIII assay factor VIII inhibitor factor IX assay factor Xa assay factor XI assay factor XIII assay heparin induced thrombocytopenia heparinase high molecular weight kininogen homocysteine hypercoagulation panel INR International sensitivity index low molecular weight heparin lupus anticoagulant mixing studies plasminogen assay plasminogen activator antigen-1 (PAI1) platelet aggregation studies platelet antibodies platelet hyperaggregation studies prekallikrein assay protein C assays protein S assays prothrombin gene 20210A PT aPTT reptilase time thrombin time tPA vWF testing-general vWF antigen analysis vWF activity vWF multimer analysis
Superpages: entire chapter
Alphabetical table of contents
A-E: abnormal PT and PTT testing acquired dysfibrinogenemia acquired thrombophilia / hypercoagulopathies-general acquired von Willebrand disease activated clotting time activated protein C resistance / Factor V Leiden activated protein C resistance / Factor V Leiden testing acute phase reaction amyloidosis anticardiolipin antibody testing antiphospholipid antibodies antiplasmin testing antithrombin antithrombin deficiency antithrombin testing aPTT testing bleeding disorders-general bleeding disorders-laboratory approach bleeding time bovine coagulation factor inhibitors clot retraction testing coagulation laboratory tests-general common pathway contact system cryoglobulin / cryofibrinogen testing D-dimer testing dabigatran testing danaparoid DIC dysfibrinogenemia ecarin clotting time elevated coagulation factors extrinsic pathway
F: factor assays factor I (fibrinogen) assay factor I (fibrinogen) deficiency factor II (prothrombin) deficiency factor V deficiency factor V inhibitor factor V Leiden testing factor VII assay factor VII deficiency factor VIII assay factor VIII deficiency (hemophilia A) factor VIII inhibitor factor VIII inhibitor testing factor IX assay factor IX deficiency (hemophilia B) factor IX inhibitor factor X deficiency factor Xa assay factor XI assay factor XI deficiency factor XII deficiency factor XIII assay factor XIII deficiency fibrinolysis pathway
G-N: hemostasis-general heparin heparin cofactor II deficiency heparin induced thrombocytopenia heparin induced thrombocytopenia testing heparin-low molecular weight heparinase testing hereditary bleeding disorders-algorithm for workup hereditary bleeding disorders-general hereditary thrombophilia / hypercoagulopathies-general high molecular weight kininogen deficiency high molecular weight kininogen testing hirudin homocysteine testing hypercoagulation panel hyperhomocysteinemia inhibitors in nonhemophilia patients INR testing International sensitivity index intrinsic pathway liver dysfunction low molecular weight heparin testing lupus anticoagulant testing lupus anticoagulants mixing studies normal hemostasis
O-Z: plasminogen activator antigen-1 (PAI1) testing plasminogen assay platelet aggregation studies platelet antibodies platelet hyperaggregation studies prekallikrein assay prekallifrein deficiency primary references protein C / S-normal protein C assays protein C deficiency protein S assays protein S deficiency proteinuria prothrombin gene 20210A testing prothrombin gene mutation (G20210A) PT testing quality assurance reptilase time sickle cell disease thrombin time thrombolytic therapy thrombomodulin tPA testing Vitamin K deficiency/warfarin von Willebrand disease vWF testing-general vWF antigen analysis vWF activity vWF multimer analysis warfarin
Primary references
top
Consultative
Hemostasis and Thrombosis: Elsevier, 2007
Massachusetts
General Hospital handbook
End of Coagulation chapter