Pathology books published by AFIP
Armed Forces Institute of Pathology / American Registry of Pathology
Revised: 12 December 2012
Copyright: (c) 2012, PathologyOutlines.com, Inc.
Table of contents
By author New books Top books
By publisher: AFIP CAP LWW WHO
Pathology Books: general surgical pathology anatomy autopsy bioterrorism board review breast cardiovascular cytopathology dermatopathology electron microscopy endocrine eye forensic GI GU grossing gynecologic head and neck hematopathology histology history IHC immunology informatics kidney lab medicine law liver lung mediastinum/serosa medical dictionaries medical writing microbiology molecular muscle neuropathology oncology other parasitology pediatric placenta soft tissue & bone statistics stem cells transfusion
Dermatology Books: cosmetic dermoscopy general infectious pediatric surgery tumors
Atlas of Nontumor pathology
Murphy: Inflammatory Disorders of the Skin (Vol 10)
By George F. Murphy, Arturo P. Saavedra, Martin C. Mihm
2012, 483 pages, $165 list
Because inflammatory skin disorders represent the most common and significant non-neoplastic skin diseases, as well as the most frequently encountered diagnostic hurdle for the practicing pathologist, they are the focus of this volume. This Atlas seeks to summarize and illuminate relevant clinical and pathologic findings for non-neoplastic disorders of skin in the context of recent knowledge and in a manner that promotes practicality. Non-neoplastic diseases of the skin are ubiquitous and numerous. They are responsible for significant morbidity in patients worldwide and account for enormous time consumption and cost within the medical community. The authors hope that this Fascicle will facilitate the diagnosis and treatment of these important conditions in a manner that will benefit patients and clinicians alike.
Klein: Non-Neoplastic Diseases of Bones and Joints (Vol 9)
By Michael J. Klein, S. Fiona Bonar, Tony Freemont, Tuyethoa N. Vinh, Robert Lopez-Ben, Herrick J. Siegel, Gene P. Siegal
2011, 980 pages, $165 list
This atlas is a histological reference for surgical pathologists not familiar or comfortable with the diagnosis of non-tumorous diseases of bones and joints. One in three physician office visits are due to bone or joint complaints; yet only one in thirty thousand orthopedic patients has a bone tumor. The diagnosis of orthopedic diseases is a complex enterprise requiring cross specialty cooperation. While contributions from orthopedic surgeons, radiologists, and rheumatologists have been included to provide more clinical relevance to this work, the emphasis is on surgical pathology of bone and joint diseases. The original and comprehensive photographs, illustrations, and tables in this reference enhance clinicopathologic correlation and diagnostic application in a way seldom provided by previous pathology resources.
Louis: Non-Neoplastic Diseases of the Central Nervous System (Vol 8)
By David N. Louis, Matthew P. Frosch, Hernando Mena, Elisabeth J. Rushing, Alexander R. Judkins
2010, 444 pages, $145 list
Of the various subspecialty areas in anatomic pathology, neuropathology tends to be one of the least familiar to general pathologists. Most surgical pathologists at institutions with neurosurgical practices gain quick familiarity with the common tumors of the central nervous system. Non-neoplastic diseases of the central nervous system, however, continue to remain a mystery to surgical pathologists, since non-neoplastic diseases of the nervous system represent a wide spectrum of relatively uncommon diseases that are not often biopsied. This Fascicle has been biased toward diseases that may be encountered in surgical pathology practice. Moreover, the authors have tried to illustrate as many entities as possible with surgical material, and have used autopsy brains primarily to illustrate key macroscopic features of some diseases. Readers will find the book of use and comfort as they realize that the brain biopsy in front of them is not from a familiar neoplasm, but from one of the sometimes challenging and always fascinating non-neoplastic diseases of the central nervous system.
O'Malley: Benign and Reactive Conditions of Lymph Node and Spleen (Vol 7)
By Dennis P. O'Malley, Tracy I. George, Attilo Orazi, Susan L. Abbondanzo
2009, 572 pages, $165 list
One of the main reasons that this Fascicle was undertaken is that for some years there has been no single, up-to-date book containing extensive information on benign and reactive lymphoid conditions. Although malignant processes garner the majority of attention, it is the benign processes that have an underlying complexity that is often an illustration of the delicate interplay of many components of the active immune system. In diagnosing the pathologic specimen, a basic approach is: 1) to determine if the process is benign or malignant, 2) if malignant, to characterize the origin of the malignancy, and 3) to subclassify or identify the process. In some cases, the first part—the question of benign versus malignant—cannot be resolved by histomorphologic evaluation alone. The second part of the approach has become considerably easier with the advent of immunophenotypic analysis. The final issue, that of identification of the pathologic process, may be of greater or lesser importance, depending on the clinical situation. If an exact diagnosis can be made, it can have several benefits. In the case of neoplastic processes, it may indicate the type of treatment and the prognosis. In benign processes, there are other important benefits as well. Although some therapies may be instituted in benign conditions, often simply naming a thing can have great benefit to the patient. It is important to realize that even in the case of a purely reactive process, finding a name, a category, a classification, can provide real peace-of-mind to the patient. As American Journal of Clinical Pathology declares, “The hundreds of images are the greatest asset of this book. There are extraordinary renditions of such exquisite classic (yet rarely illustrated) entities: ‘sago’ and ‘lardaceous’ spleens, ‘lollipop’ and ‘explosive’ lymphoid follicles, multinucleated measles cells and hyperplastic mesothelial inclusions, and sundry mystifying diseases, including those known eponymously: Kawasaki, Kikuchi, and Kimura.” Am J Clin Pathol 2010; 133:818 For pathologists, and hematopathologists specifically, Drs. O’Malley, George, Orazi, and Abbondanzo have created a book that will serve for years as a useful guide to the multifaceted world of benign and reactive lesions of the lymphoid system.
Foucar: Non-Neoplastic Disorders of Bone Marrow (Vol 6)
By Kathryn Foucar, David S. Viswanatha, Carla S. Wilson
2009, 409 pages, $130 list
This Fascicle on non-neoplastic disorders is devoted to the assessment of bone marrow in pediatric and adult patients, though neoplastic processes are briefly highlighted in discussions of differential diagnostic considerations. Lineage-based non-neoplastic erythroid, myeloid, megakaryocytic, and lymphoid disorders are discussed as well as bone marrow findings in patients with systemic, nonhematologic disorders. A standardized format is used to the best extent possible for each chapter, with an emphasis on categorizing disorders based on patient age, constitutional versus acquired conditions, and pathogenetic mechanism. Because of this combined lineage-based and disease-based approach, there is some unavoidable overlap of content between chapters. Cross referencing refers the reader to the specific chapter with the most comprehensive discussion.
Kraus: Placental Pathology (Vol 3)
By Frederick T. Kraus, Raymond W. Redline, Deborah J. Gersell, D. Michael Nelson, Jeffrey M. Dicke
2004, 331 pages, $95 list
Over 490 illustrations The third Fascicle of the Atlas of Nontumor Pathology offers a concise guide to understanding the placenta; a unique organ involving both mother and child during pregnancy. The book, Placental Pathology, is divided into fourteen chapters and an appendix. It includes the structure and function of the normal placenta and then proceeds to review the major disorders and lesions, which occur as complications of a normal pregnancy and delivery. The monograph includes not only pathology authors but also an obstetrician and radiologist who present an expert comprehensive review of diseases of the placenta. It is therefore a valuable reference for all three specialty groups in this field.
Travis: Non-Neoplastic Disorders of the Lower Respiratory Tract (Vol 2)
By William D. Travis, Thomas V. Colby, Michael N. Koss, Melissa L. Rosado-de-Christenson, Nestor L. Müller, Talmadge E. King, Jr
2002, 939 pages, $195 list
This second fascicle of the Atlas of Nontumor Pathology addresses one of the most difficult areas in surgical pathology. Recognizing the need for a multidisciplinary approach to the successful diagnosis of many of these diseases, a pulmonologist and two radiologists have been included as authors to supplement the pathology contributions. With their clinical and radiological expertise, Drs. King, Rosado-de-Christenson, and Miller have greatly enhanced the pathology descriptions. A 939-page volume has resulted with a total of 1,185 color and 284 black and white images, including pathology as well as radiology illustrations. When appropriate, the importance of clinical, radiological, and pathologic correlation is emphasized. The radiology images include characteristic manifestations on chest radiography and high-resolution computed tomography. This reference will be helpful to clinicians, radiologists, and pathologists seeking a better understanding of this difficult subject.
Lloyd: Endocrine Diseases (Vol 1)
By Ricardo V. Lloyd, Bruce R. Douglas, William F. Young
2002, 315 pages, $120 list
The purpose of the Atlas is to provide surgical pathologists with ready expert reference material most helpful in their daily practice. The lesions described relate principally to medical non-neoplastic conditions as exemplified by our first three Fascicles on endocrine, pulmonary, and skin diseases. Many of these lesions represent complex entities and when appropriate, we have included contributions from internists, radiologists, and surgeons. This has led to some increase in the size of the monographs but the emphasis remains on diagnosis by the surgical pathologist. Previously, the Fascicles have been available on CD-ROM format as well as in print. In order to provide the widest possible advantages of both modalities, we have formatted the print Fascicle on the World Wide Web. Use of the Internet allows cross-indexing within the Fascicles as well as linkage to MedLine. Our goal is to continue to provide expert information at the lowest possible cost. Therefore, marked reductions in pricing are available to residents and fellows as well as to staff purchasing on a subscription basis. We believe that the Atlas of Nontumor Pathology will serve as an outstanding reference for surgical pathologists as well as an important contribution to the literature of other medical specialties.
Fourth Series - Atlas of Tumor Pathology
Epstein: Tumors of the Prostate Gland, Seminal Vesicles, Penis, and Scrotum (Vol 14)
By Jonathan I. Epstein, Antonio L. Cubilla, Peter A. Humphrey
2011, 675 pages, $165 list
This fourth series Fascicle in the American Registry of Pathology/Armed Forces Institute of Pathology Atlas of Tumor Pathology series discusses the practical pathologic diagnoses of tumors and tumor-like diseases of the prostate gland, seminal vesicles, penis, and scrotum. The authors follow the tradition of the preceding three Fascicles by emphasizing pathologic gross and light microscopic diagnostic features and differential diagnoses. They also discuss relevant clinical features, including concise sections on the clinical presenta tion and the clinical meaning of the pathologic diagnosis in terms of prognosis and treatment. The immunohistochemical and molecular pathologic studies that are of current value in diagnosis are clearly presented. The high quality images follow the rich tradition of the previous Fascicles to depict the spectrum of tumor morphology from cases mainly from the files of institutions such as The Johns Hopkins Hospital, Barnes-Jewish Hospital, and Instituto de Patología e Investigación. This Atlas will be of great value in the field of pathology of the prostate gland, seminal vesicles, penis, and scrotum for years to come.
Kurman: Tumors of the Cervix, Vagina, and Vulva (Vol 13)
By Robert J. Kurman, Brigitte M. Ronnett, Mark E. Sherman, and Edward J. Wilkinson
2010, 431 pages, $150 list
The publication of this Fascicle marks the transition in diagnosis of lower genital tract lesions from a largely morphologic activity to one based upon integrated assessment using microscopy and molecular biology. Furthermore, the ability to integrate these diagnostic approaches with clinical data for patient management has been heightened. The introduction of prophylactic vaccines for preventing human papillomavirus (HPV) infections and cervical cancer precursors also thrusts pathology into a new unprecedented public health role with regard to disease monitoring, which will likely expand over time.Finally, the realization that cervical cancer is becoming increasingly preventable, carries with it both a sense of accomplishment and the recognition that this must now be translated into an achievable goal of cancer prevention in underdeveloped nations. Although the text has remained concise in order to maintain the primary function of the Fascicle as an atlas rather than a comprehensive textbook, it has been substantially updated to reflect the changes in the field since the previous edition was published in 1992. In this regard, the number of illustrations, all of which are in color, has almost doubled. Both the text and the photomicrographs emphasize the importance of immunohistochemistry andmolecular in situ hybridization as adjuncts to morphology in routine clinical diagnosis. A binary (low-grade and high-grade squamous intraepithelial lesion) classification for histology, analogous to TBS for cytology, replaces the four-tiered dysplasia/CIS system and the three-tiered CIN system. This Fascicle will be a useful reference for pathologists, residents, and students for years to come.
Elder: Melanocytic Tumors of the Skin (Vol 12)
By David E. Elder, George F. Murphy
2010, 468 pages, $165 list
In surgical pathology practice, distinguishing malignant from benign melanocytic lesions represents one of the major problem areas. Failure to diagnose a malignant melanoma can have catastrophic results, but separating melanomas from their simulants is often difficult, and over-diagnosis of melanoma is also inappropriate. This fascicle presents a comprehensive account of benign and malignant melanocytic lesions. The benign lesions encompass the major simulants of melanoma. In addition, some of them, such as dysplastic nevi, have significance as markers of individuals at increased risk for the development of melanoma. It has become ever more apparent, especially with the recent advent of molecular classification, that melanoma is not one disease, and that prognosis in melanoma can vary considerably from lesions that present minimal risk, to dangerous malignancies at opposite ends of a spectrum. The details of therapy for these lesions are very different and are determined for the most part by their diagnostic and prognostic features as judged by microscopy. This fascicle explains in detail the use of attributes for microstaging and for prediction of prognosis in melanoma, including discussion of the latest AJCC staging system. More importantly, however, it provides a richly illustrated roadmap for diagnosis of the entire spectrum of melanocytic tumors. Discussion of the lesions is firmly grounded in their clinical significance, with detailed descriptions of clinical features often accompanied by clinical images. Lesions in general are illustrated in multiple microscopic images ranging from scanning magnification to high power. Cytologic as well as architectural features are clearly delineated. Pathophysiology, epidemiology, and molecular attributes are also discussed. This work will serve as a comprehensive text for learning on the part of trainees, and also as an invaluable diagnostic reference for more experienced diagnosticians in daily practice.
Shimosato: Tumors of the Mediastinum (Vol 11)
By Yukio Shimosato, Kiyoshi Mukai, Yoshihiro Matsuno
2010, 322 pages, $135 list
Since the publication of the AFIP Third Series fascicle in 1997, the World Health Organization (WHO) has printed two major volumes concerning tumors of the thymus. Drs. Mukai and Shimosato, who are not only two of the authors of Tumors of the Mediastinum but also co-authors of the Third Series fascicle, were collaborators on the WHO volumes. In the last 10 years, little progress has been made in the study of tumors of the thymus, although a few new subtypes have been reported. The most significant change was the subtyping by the WHO of tumors of the thymus that do not cause constitutional changes. The present Fascicle has adopted the WHO system of classification. For pathologists who are not as familiar with the WHO system, the authors extensively explain and illustrate both the morphologic and histogenetic classification systems that are its bases. Due to the changes in nomenclature, the chapter on thymic epithelial tumors has been considerably revised. The main diagnostic terms are presented along with the previous conventional morphologic and histogenetic terms, for the readers’ sake. Newly recognized tumor entities, new cytologic and genetic findings, and recent references have been added. Tables have been revised to reflect new data on survival, staging, and classification. This volume will be an authoritative reference on mediastinal tumors for years to come.
Tavassoli: Tumors of the Mammary Gland (Vol 10)
By Fattaneh A. Tavassoli, Vincenzo Eusebi
2009, 418 pages, $150 list
This tenth fascicle of the Atlas of Tumor Pathology focuses on the morphology of breast legions. This volume is composed of 18 chapters, an appendix, and contents sections. It contains 474 figures, some of which include more than one image. All illustrations in this 418-page book are in full color. Ductal proliferative lesions and in situ ductal carcinomas are evaluated according to Dr. Tavassoli's ductal intraepithelial neoplasia (DIN) terminology. A chapter on DIN provides an update of Dr. Tavassoli's current approach and, moreover, gives the reader a chance to understand the proposed differences compared to WHO classification. Breast carcinomas are discussed in three categories: major types, low-grade carcinomas, and rare carcinomas. The definitions of tumor types; alternative terminologies; macroscopic, micrscopic, and cytologic findings are comprehensively detailed. This Atlas will serve as a guide to both general and breast pathologists on the way to diagnosis.
Ellis: Tumors of the Salivary Glands (Vol 9)
By Gary L. Ellis, Paul Auclair
2008, 524 pages, $165 list
This volume builds upon the work of its predecessor in the third series of the Atlas of Tumor Pathology, liberally illustrating the spectrum of each tumor and disease described, while providing many new illustrations. Morphometry, flow cytometry, immunohistochemistry, gene rearrangement studies, and other molecular biologic methodologies are exciting new areas that are being developed into diagnostic procedures in the pathology laboratory. Where these methodologies are applicable to salivary gland disease, they are included. Histomorphologic evaluation, however, remains the principal and most useful method for diagnosis of salivary gland tumors and is the emphasis of this Fascicle. A differential diagnosis is included in the discussion of most tumors, and the cytopathologic features of those tumors most commonly encountered in the cytopathology laboratory are discussed.
Burger: Tumors of the Central Nervous System (Vol 7)
By Peter C. Burger, Bernd W. Scheithauer
2007, 596 pages, $185 list
In the decade since the publication of the Third Series Fascicle on Tumors of the Central Nervous System, many new entities have been described, prognostic significance of certain tumor subtypes established, grading systems revised, and molecular features have been correlated with tumor types and grades. Drs. Burger and Scheithauer have integrated all of these new findings, as well as classical morphological clinical and neuroradiological descriptions and illustrations, into an entirely new and completely up-to-date text/atlas that demystifies the complex subject of CNS tumors and tumor-like lesions for the general pathologists. The discussion of normal anatomy includes cytologic and radiologic correlations, as do discussions of each of the common and rare CNS lesions. Virtually all of the non-radiographic illustrations are in color, and references are current through 2006 and 2007 (the 2007 World Health Organization classification is used throughout the Fascicle). In addition to encyclopedic coverage of CNS neoplasms, approximately 15 percent of the almost 600 text pages are devoted to the numerous benign tumor-like lesions of various etiologies that may be mistaken for neoplasms. A set of fifteen Appendices is devoted to differential diagnostic algorithms which simplify the approach to a difficult specimen. The authoritative yet user-friendly approach of the authors has created a work that will be useful for many years to both pathologist and clinicians interested in tumors of the central nervous system.
Hruban: Tumors of the Pancreas (Vol 6)
By Ralph H. Hruban, Martha Bishop Pitman, David S. Klimstra
2007, 422 pages, $150 list
In this Atlas of Tumors of the Pancreas, Drs. Hruban, Pitman and Klimstra succinctly summarize the clinical literature, but concentrate on both new entities and new concepts, described since the publication of the Third Series Fascicle ten years ago. The illustrations, with the exception of radiographs and electron micrographs, are in color, and tumors are presented in detail. The continuing importance of tumor morphology in directing molecular studies is appropriately emphasized. In addition to the extensive discussion, illustrations, and up-to-date referencing of the numerous pancreatic tumors and tumor-like lesions, important discussions have been provided on normal gross, histologic and cytologic findings, and on pancreatic tumor staging. These discussions compliment the authors’ treatment of the often confusing issue of frozen section interpretation, dissection, and reporting of pancreatic resection specimens, and an "unknown" pancreatic biopsy or cytology specimen. This volume should be the definitive reference on pancreatic tumor for years to come.
Font: Tumors of the Eye and Ocular Adnexa (Vol 5)
By Ramon L. Font, J. Oscar Croxatto, Narsing A. Rao
2006, 339 pages, $135 list
When a specimen representing a tumor or tumor-like lesion of the eye or ocular adnexa is received in most general surgical pathology laboratories, the immediate reaction is one of panic, because these tumors are rarely encountered and often require complex gross dissections, based on a knowledge of ocular anatomy, which most general surgical pathologists either never possessed or have long since forgotten. Drs. Font, Croxatto, and Rao state that their main objective is to emphasize the important features of these lesions that are of special interest to general and surgical pathologists. In addition to providing complete descriptions of the tumors and tumor-like lesions in the various compartments of the eye and ocular adnexa, the authors correlate the pathologic features with epidemiologic and pathogenetic observations, clinical features, differential diagnosis, and special studies including immunohistochemistry and various molecular approaches. Each anatomic site has a section on normal anatomy and histology, and there is a separate chapter on the pathologic examination of ocular specimens, so that the general pathologist can approach these uncommonly encountered specimens with confidence. Because of its scholarly, practical, well illustrated and well referenced approach, this work will appeal to pathologists and ophthalmologists alike.
Patterson: Nonmelanocytic Tumors of the Skin (Vol 4)
By James W. Patterson and Mark R. Wick
2006, 524 pages, $165 list
Nonmelanocytic tumors of the skin form a large and heterogeneous group of lesions, ranging from common to extremely rare, which often appear to the practicing pathologist to blend into one another and difficult to identify correctly, especially in specimens, which often represent limited biopsies. There may be more different entities in this group than in any other organ system. The table of contents of this encyclopedic work by Drs. Patterson and Wick reveals a total of 226 tumors and tumor-like lesions discussed by the authors. For each of these entities, the authors present the distinctive clinical and pathologic features, as well as an extensive differential diagnosis. Special studies, including immunohistochemistry, electron microscopy, and molecular profiles are presented where appropriate. The text is complemented by over 880 illustrations (almost exclusively in color) and over 3,000 references through 2005. This publication and the forthcoming volume on Melanocytic Tumors will serve as the most comprehensive and useful guides available to cutaneous tumors and tumor-like lesions.
Churg: Tumors of Serosal Membranes (Vol 3)
By Andrew Churg, Philip T. Cagle, and Victor L.Roggli
2006, 147 pages, $75 list
The pathologist who sees specimens from lesions of the serosal membranes (pleura, pericardium, peritoneum, and tunica vaginalis) is well aware that these cases, whether in the form of fluid cytologies, small biopsies, or major resections, pose differential diagnostic problems that are among the most difficult in anatomic pathology. The main problems involve the separation of malignant mesothelioma from benign mesothelial processes on the one hand and other malignant tumors (particularly primary and metastatic carcinomas) on the other. With these differential diagnoses in mind, Drs. Churg, Cagle, and Roggli concentrate on the cytopathologic and histopathologic features of diffuse malignant mesothelioma, its many variants, and the other benign and malignant lesions to be distinguished from it. Histochemical, immunohistochemical, ultrastructural and molecular features of potential use in this differentiation are discussed and illustrated. Common differential diagnostic problems and their solutions take precedence, but all of the known benign and malignant lesions of serosal membranes are covered, with copious illustrations and the latest available references. Epidemiologic, pathogenetic, clinical, radiographic and gross pathologic features are integrated with the discussions of these entities. This will be the most complete source available on this topic for years to come.
Unni: Tumors of the Bones and Joints (Vol 2)
By K. Krishnan Unni, Carrie Y. Inwards, Julia A. Bridge, Lars-Gunnar Kindblom and Lester E. Wold
2005, 339 pages, $125 list
One of the goals of the Fourth Series Tumor Fascicles is the presentation of new molecular findings which add to our understanding of tumor pathogenesis and may additionally be useful diagnostically. Such information is particularly relevant to the study of bone tumors and tumor-like lesions, and Drs. Unni, Inwards, Bridge, Kindblom and Wold have included an up-to-date summary of where pathologists stand in the application of these new data in this volume. The authors are also well aware that the primary mission of the Fascicles is to help the practicing pathologist diagnose a difficult case correctly, and for most pathologists, any lesion in a bone is potentially problematic. Thus, the important diagnostic feature of each major lesion (including all known variants) is presented in detail. This includes not only the gross, histopathologic, and cytologic findings, but also the clinical and radiographic features of particular importance in the differential diagnosis of bone tumors and their mimics. Most illustrations of pathologic features are now in color, and the classic references in this field have been complemented by extensive current literature citations. This volume should prove to be useful for many years.
Murphy: Tumors of the Kidney, Bladder and Related Urinary Structures (Vol 1)
By William M. Murphy, David J. Grignon, Elizabeth J. Perlman
2004, 394 pages, $120 list
Since the publication of the Third Series Fascicle on Tumors of the Kidney, Bladder, and Related Urinary Structures in 1994, there has been a revolution in our understanding of the clinical, pathologic, and molecular features of these lesions. Thus, it is fitting that this volume should be the first of the Fourth Series Tumor Fascicles. In the Fourth Series in general, and in this fascicle in particular, there is an increased emphasis on new molecular findings which are relevant to diagnostic tumor pathology, as well as on the diagnostic features of aspiration and exfoliative cytopathology. Differential diagnosis is also emphasized, and numerous tables summarize important differential diagnostic considerations, including the appropriate roles of immunohistochemical stains. Important recommendations for gross dissection and surgical pathology report construction are also included. Drs. Murphy, Perlman, and Grignon have expanded the Third Series Fascicle by approximately twenty percent, and almost all of the 586 illustrations are now in color. The 1530 references in five chapters are comprehensive and up to date.
Third Series - Atlas of Tumor Pathology
Ishak: Tumors of the Liver and Intrahepatic Bile Ducts (Vol 31)
By Kamal G. Ishak, Zachary D. Goodman and J. Thomas Stocker
2001, 356 pages, $90 list
In the 12 years since publication of the second series fascicle on this subject, there have been many advances in epidemiologic, histogenetic, pathogenetic, and clinicopathologic aspects of tumors and tumor-like lesions of the liver and intrahepatic bile ducts. This third series fascicle is divided into 14 chapters: Embryology, histology, and anatomy. Benign hepatocellular tumors. Benign cholangiocellular tumors. Benign mesenchymal tumors and pseudotumors. Miscellaneous benign tumors and pseudotumors. Hepatoblastoma. Putative precancerous lesions. Hepatocellular carcinoma. Fibrolamellar hepatocellular carcinoma. Intrahepatic cholangiocarcinoma and other malignant biliary tumors. Miscellaneous malignant tumors. Malignant mesenchymal tumors. Primary hepatic lymphomas and suspected lymphomas. Metastatic tumors and an appendix on the TNM classification of malignant tumors of the liver. Several tumors and tumor-like lesions are extensively discussed, commensurate with increased knowledge about them, such as peribiliary gland hamartoma (bile duct adenoma), hepatobiliary cystadenoma, biliary papillomatosis, lymphangioma, angiomyo-lipoma, miscellaneous heterotopias, hepatoblastoma, hepato-cellular carcinoma, intrahepatic cholangiocarcinoma, epithelioid hemangioendothelioma, and primary hepatic lymphomas (including a section on diagnosis of suspected lymphoma).
Kempson: Tumors of the Soft Tissues (Vol 30)
By Richard L. Kempson, Christopher D.M. Fletcher, Harry L. Evans, Michael R. Hendrickson and Richard K. Sibley
2001, 507 pages, $105 list
The field of soft tissue tumors is complex and challenging because of the large number of soft tissue tumor types; the often, and subtle, histologic differences between them; and the rarity of many soft tissue neoplasms. This AFIP fascicle provides a practical approach to the diagnosis of soft tissue tumors as well as a comprehensive morphological description and differential diagnosis for each of the well-characterized tumor types. Pertinent clinical and prognostic information accompanies the description of each tumor. Diagnostically useful immunohistochemical staining patterns and cytogenetic abnormalities with potential diagnostic utility are an integral part of the discussion. The following are a few of the topics discussed in detail: The importance of utilizing a managerial as well as a scientific classification when reporting on soft tissue tumors. Distinguishing morphologically bland, but clinically malignant, lesions such as low-grade fibromyxoid sarcoma from benign mimics. The reasons for retaining the category of the so-called fibrous histiocytomas. Myxoid lesions of the soft tissue. Atypical lipomatous tumors and dedifferentiated liposarcomas. Spindle cell/pleomorphic lipoma vs atypical lipomatous tumor. Problematic smooth muscle tumors of the soft tissues and retroperitoneum. The differential diagnosis of small round blue cell tumors. Tumors of the soft tissues with constituent cells of an epithelioid phenotype. The morphologic features most useful in classifying vascular tumors. With 696 color illustrations and a comprehensive 507-page text, this fascicle represents a major source of information about soft tissue tumors. Peripheral nerve sheath tumors are covered in a separate fascicle.
Sciubba: Tumors and Cysts of the Jaw (Vol 29)
By James J. Sciubba, John E. Fantasia and Leonard B. Kahn
2001, 275 pages, $70 list
This presentation of tumors and cysts of the mandible and maxilla discusses 71 separate pathologic entities. The authors, three pathologists with extensive experience in the interpretation of jaw lesions, have utilized 353 radiographs, photomicrographs, and sketches to illustrate the wide range and scope of bone pathology within this unique part of the skeletal system. Normal embryogenesis and development of the jaws and dentition, histology of odontogenesis, and classification of tumors and cysts are covered. A comprehensive and broad array of benign, malignant, and dysplastic lesions includes odontogenic, nonodontogenic, and fibro-osseous lesions of the jaws. Representative plain radiographs, computerized tomographic images, and color photomicrographs form the basis for clinicopathologic correlation. Routine diagnostic procedures and stains are stressed as the basis for establishment of a definitive diagnosis. As a result, this volume will be an essential resource for pathologists, radiologists, and clinicians charged with establishing a diagnosis and treatment plan for patients with tumors and cysts of the jaws.
Young: Tumors of the Prostate Gland, Seminal Vesicles, Male Urethra, and Penis (Vol 28)
By Robert H. Young, John R. Srigley, Mahul B. Amin, Thomas M. Ulbright, and Anthony L Cubilla
2000, 512 pages, $105 list
Many important advances have been made in the publication of the second series fascicle on this topic in 1973. The publication of this work is especially timely given the explosion of interest in the pathology of the prostate gland, and the current large volume of difficult prostatic biopsy specimens. Although accounting for a much lesser number of specimens, the pathology of the seminal vesicles, male urethra, and penis provides diverse challenges in interpretation. Furthermore, carcinoma of the penis, which is relatively common in certain parts of the world, has been the subject of a number of important recent studies. Accurate pathologic interpretations of all the entities that may be encountered in these regions, and the sometimes challenging distinction between benign and malignant, have major therapeutic implications.This fascicle emphasizes the differential diagnosis of carcinoma of the organs considered, particularly the distinction of carcinoma from mimics of cancer, tumor grading, and pathologic information of prognostic significance. It begins with a consideration of the normal anatomy and histology of the prostate gland followed by discussion of prostatic hyperplasia and the precursors of prostatic adenocarcinoma. The ensuing three chapters discuss conventional carcinoma of the prostate gland, variants of prostatic cancer, and miscellaneous other prostatic tumors. The final chapter on the prostate reviews in detail the numerous benign proliferations that may potentially be misinterpreted as neoplastic. Individual chapters are devoted to the seminal vesicles, male urethra, and penis. The emphasis of this work remains routine light-microscopic interpretation, which is diagnostic in the great majority of cases. The role of immunochemistry is emphasized where appropriate, for example, in the evaluation of problematic prostate proliferations and in confirming the prostate cell type of certain benign and malignant lesions. This 512-page fascicle, written by five pathologists with extensive experience evaluating genitourinary pathology, includes 835 color and 83 halftone illustrations. Every effort has been made to include the most current references as well as important contributions from the older literature.
Albores-Saavedra: Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater (Vol 27)
By Jorge Albores-Saavedra, Donald Earl Henson, and David S. Klimstra
2000, 365 pages, $85 list
Tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater are uncommon and show a broad morphologic spectrum. Because of their rarity and unusual morphologic features, some of these tumors pose a real challenge to the pathologist. Their exact histologic classification, however, is essential for therapeutic and prognostic purposes. Moreover, a wide variety of tumorlike lesions that arise at these anatomic sites complicate the differential diagnosis. In this third series fascicle, the gross, microscopic, immunohistochemical, and ultrastructural features of benign and malignant tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater are illustrated and discussed in detail. In addition to the common adenocarcinomas, many other tumor types including clear cell, undifferentiated, and small-cell carcinomas; adenomas; and mesenchymal, lymphoid, and endocrine neoplasms, are included. The association of endocrine tumors with clinical syndromes is emphasized. When appropriate, information about molecular pathology is included. Valuable epidemiologic data and prognostic factors for gallbladder, extrahepatic bile duct, and ampullary carcinomas are provided. This 365-page fascicle, which includes 628 illustrations (most of which are in color), should be an essential reference for residents, oncologists, and pathologists in practice.
Mills: Tumors of the Upper Aerodigestive Tract and Ear (Vol 26)
By Stacey E. Mills, Michael J. Gaffey and Henry F. Frierson, Jr.
2000, 450 pages, $95 list
Although many tumors of the upper respiratory tract are squamous cell carcinomas, the varied tissues of this region can give rise to a bewildering array of neoplasms. Even the recognition of squamous cell carcinoma can be quite challenging if one is confronted with a diagnostically problematic variant form. This 450-page fascicle is based on the extensive experience of three surgical pathologists who have frequently dealt with these problems, both in consultation material and in the day-to-day diagnostic challenges of a busy, nationally recognized ENT surgery service. This text reviews the full spectrum of neoplasms and neoplasmlike entities arising in the head and neck region, including the ear. (Salivary gland neoplasms have been discussed in a separate fascicle.) There are 544 high-quality 4-color and 49 halftone illustrations. Emphasis is placed on a pragmatic approach to differential diagnosis, with ample discussion of clinical features as well as ancillary diagnostic techniques, including immunohistochemistry. The fascicle begins with a review of pertinent normal anatomy and histology. The clinically and diagnostically significant variants of benign squamous neoplasia, squamous dysplasia, and squamous cell carcinoma are reviewed in detail, with appropriate emphasis on diagnostic pitfalls and their avoidance. The spectrum of non-salivary glandular neoplasms, including intestinal-type carcinomas, is presented. Entire chapters are devoted to variants of neural and neuroendocrine neoplasia as well as lymphoid neoplasms of this region. In the latter chapter, for example, the often confusing topic of T/NK cell lymphoma and the bewildering array of prior terms and concepts applied to this process are discussed in detail. Separate chapters also are devoted to vascular, fibrous, osseous, germ cell, and miscellaneous soft tissue tumors that predilect or exclusively involve this region. An additional chapter discusses diagnostically problematic tumorlike lesions, including necrotizing sialometaplasia, myospherulosis, respiratory epithelial adenomatoid hamartoma, teflon granuloma, rhinoscleroma, and similar topics. The fascicle concludes with an extensive review of benign and malignant tumors of the external, middle, and inner ear. This book should serve as an invaluable resource for pathologists confronted with these common and often troublesome specimens.
Ulbright: Tumors of the Testis, Adnexa, Spermatic Cord, and Scrotum (Vol 25)
By Thomas M. Ulbright, Mahul B. Amin and Robert H. Young
1999, 385 pages, $90 list
A number of important advances have been made in testicular tumor pathology since the publication of the 2nd series fascicle, Tumors of the Male Genital System, necessitating a separate atlas devoted to the testis, its adnexa, spermatic cord, and scrotum to incorporate this new information. The publication of this work is timely, as the incidence of testicular cancer in many countries continues to increase. Because of the need for effective, yet different, therapeutic approaches for many entities, accurate pathologic interpretation of these tumors, most of which occur in young patients, is of paramount importance.This atlas emphasizes the differential diagnosis of testicular tumors. It begins with a consideration of general aspects, including epidemiology, followed by a discussion of the histogenesis of germ cell tumors, including the lesion known as “intratubular germ cell neoplasia, unclassified type.” Typical seminoma is considered and illustrated in detail, as well as variants such as tubular seminoma, seminoma with cribriform patterns, spermatocytic seminoma, and spermato-cytic seminoma with sarcoma. Also thoroughly covered are nonseminomatous germ cell tumors and sex cord-stromal tumors. An entire chapter is devoted to the many non-neoplastic lesions of this region that are, in some instances, easily misinterpreted as neoplastic. The final chapter is devoted to the scrotum. Newer diagnostic approaches, e.g., immunohistochemical and molecular analyses, are discussed as supplemental methods; however, the emphasis of this work remains routine light-microscopic interpretation. Where appropriate, the diagnostic utility of ultrastructure is considered. In addition the clinical significance of each lesion is discussed. This 385-page atlas, written by three pathologists with extensive experience evaluating testicular pathology includes 535 color and 42 halftone illustrations. Every effort has been made to include the most current references as well as important contributions from the older literature.
Scheithauer: Tumors of the Peripheral Nervous System (Vol 24)
By Bernd W. Scheithauer, James M. Woodruff and Robert A. Erlandson
1999, 421 pages, $95 list
Since publications if the 2nd series fascicle on Tumors of the Peripheral Nervous System, the spectrum of the nerve pathology has markedly expanded. Newly described lesions in this 3rd series fascicle are numerous. Among tumorlike lesions are reactive processes such as inflammatory pseudotumor, hyperplastic lesions including palisaded encapsulate neuroma, and localized hypertrophic neuromuscular choistoma. Benign tumors are cellular schwannoma , a lesion frequently mistaken for malignant peripheral nerve sheath tumor, psammomatous melanotic schwannoma with or without a syndrome association (Carney's complex), intraneural perineurioma, and neurothekeoma. Also described since publications of the 2nd series fascicle are such malignant neoplasma ap purely epithelioid malignant peripheral nerve sheath tumor, glanduar MPNST, MPNSTs derived from schwannoma, and MPNST with perineurial differentiation. The last chapter provides,heavily illustrated presentation of neuroofibromatosis . In order to provide insight the evolution of peripheral nerve lesions, the fascilce begins with a concise, richly illustrated introductory chapter on normal gross and microscopic anatomy of the peripheral nervous system. In typical fascicle format, pathologic features are presented in terms of their gross, histologic, and immunochemical aspects. In addition, the fascicle stresses the utility of electron microscopy in elucidating the nature of lesions and in differential diagnosis. The application of this modality has contributed immensely to our understanding of the normal structure and function of the peripheral nervous system. Practicality, long the hallmark of the Atlas series, is the thrust of this work. Valuable epidemiologic, clinical, and even neruroradiologic correlation is provided, as is clinically correlative data regarding prognostic indicators and syndrome association. This 421-page fascilce includes over 900 illustrations, 841 of which are in color. It should be an essential reference for pathologists in practice and training.
Scully: Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, & Broad Ligament (Vol 23)
By Robert E. Scully, Robert H. Young and Philip B. Clement
1998, 527 pages, $95 list
The authors are grateful to the many pathologists who over the years have submitted interesting cases for consultation, providing the authors with a broad experience in the subject matter of this Fascicle. The reviewers of the initial manuscript offered many helpful suggestions, which have enabled us to improve the clarity of the text. We owe special thanks to Dr. Debra A. Bell and Dr. Judith A. Ferry of the Massachusetts General Hospital and Dr. Arthur L. Herbst of the Chicago Lying-In Hospital for reviewing specific sections of the text. Mrs. Marlene Fairbanks typed the manuscript and Mr. Stephen Conley and Ms. Michelle Forrestall provided photographic assistance. Finally, we wish to thank the editorial staff of UAREP for their support and patience.
Asa: Tumors of the Pituitary Gland (Vol 22)
By Sylvia L. Asa
1998, 214 pages, $60 list
This monograph represents a comprehensive review of the various tumors and tumorlike lesions that involve the pituitary gland and the sellar region. It features a clinicopathologic approach to the diagnosis of pituitary adenomas and a systematic review of other sellar and parasellar tumors that present with mass effects and/or endocrine syndromes. The text reviews normal anatomy, embryology, and cytology as well as hormonal function and regulation. New Aspects of the molecular regulation of cell differentiation and hormone function are included. One chapter is dedicated to practical issues of specimens handling, including the diagnostic roles of intraoperative consultation, conventional histology and special stains, immunohistochemical, electron microscopy, genetic analysis, and other techniques. Clinicopathologic correlates in pituitary adenomas are emphasized, with descriptions and illustrations of clinical manifestations, biochemical data, and radiological findings relevant to the pathological diagnosis of all major entities. Morphologic features of each tumor are lavishly illustrated; differential diagnosis are discussed in detail; and a large portion of the monograph is dedicated to other tumors and non-neoplastic lesions that occur in the region of the sella turcica. Prognostic implications and therapeutic approaches are reviewed for each pathological entity. Every chapter has an extensive and up-to-date bibliography. In 214 pages and 295 figures (200 in color), this volume emphasizes practical issues in diagnosis and potential pitfalls, while including essential basic information. This fascicle will serve as a valuable resource for pathologists as well as endocrinologists, neurologists, neurosurgeons, radiologists, and scientists with an interest in the diagnosis, cytogenesis, and pathogenesis of pituitary disease.
Burke: Tumors of the Heart and Great Vessels (Vol 16)
By Allen Burke and Renu Virmani
1996, 231 pages, $58 list
The entirely new fascicle on tumors of the cardiovascular system is a comprehensive, 231-page text covering over 50 distinct tumors and tumorlike lesions of the heart and great vessels. Opening the 16-chapter volume are discussions of embryology, overview and incidence of tumors of the heart, and general pathologic and clinical approaches to cardiac tumors. Entities are discussed by putative cell of origin, with emphasis on histogenesis, clinical presentation, radiographic features, gross and microscopic features, and differential diagnosis. Immunohistochemical and ultrastructural findings, where helpful in diagnosis, are discussed and illustrated. A final chapter on metastatic tumors covers the differential diagnosis of metastatic pericardial disease and metastatic tumors to myocardium. There is special emphasis on cardiac myxoma and cardiac sarcomas, which represent the most common primary tumors of the heart, as well as an extensive chapter on mesotheliomas of the pericardium. Newly described lesions, such as cardiac MICE and post-transplant lymphoproliferative diseases, are discussed and illustrated. The text is lavishly illustrated, with over 270 illustrations of gross and microscopic images. The text relies on the vast repository of cardiac tumors at the AFIP as well as on extensive literature citations, emphasizing the most recent references in the 1990's through 1995. There are 18 tables emphasizing incidence, classification, clinical findings, syndromes associated with cardiac tumors, and prognostic data of cardiac sarcomas.
Battifora: Tumors of the Serosal Membranes (Vol 15)
By Hector Battifora and W.T. Elliott McCaughey
1995, 128 pages, $45 list
Since the appearance of the second series fascicle on this topic, there has been considerable growth in our knowledge of these neoplasms, including wider recognition of types of mesothelioma with unusual microscopic features or behavioral patterns. Recent progress in the application of immunohistochemistry has led to more accurate histological diagnosis of mesothelioma and has made it easier to recognize those nonmesothelial tumors mimicking mesothelioma. Nonetheless, hematoxylin and eosin-stained preparations remain the mainstay of diagnosis of serous membrane tumors. Thus, due emphasis is placed on conventional histological findings in this new fascicle, while at the same time expanding the coverage of important diagnostic tests such as immunohistochemistry. In addition to the malignant mesotheliomas, attention is given to other mesothelial-related tumors such as primary serous papillary carcinoma of the peritoneum, multicystic mesothelioma, intra-abdominal desmoplastic round cell tumor, adenomatoid tumor, localized fibrous tumor, and the so-called mesothelioma of the atrioventricular node. Concise tables depict such features as: the differential diagnosis of diffuse malignant mesothelioma; the comparison of histologic features of mesothelial hyperplasia, mesothelioma, and carcinoma; and the immunohistochemistry of peritoneal mesothelioma and serous carcinoma. The fascicle is 128 pages long and includes over 150 illustrations, 104 of which are in color. It should be an essential reference for pathologists in practice and in training.
McLean: Tumors of the Eye and Ocular Adnexa (Vol 12)
By Ian W. McLean, Miguel N. Burnier, Lorenz E. Zimmerman and Frederick A. Jakobiec
1995, 322 pages, $56 list
This monograph offers a comprehensive review of the wide variety of tumors that occur in the eyelid, conjunctiva, retina, uveal tract, lacrimal gland and sac, orbit, and optic nerve. Over the four decades since publication of the First Series fascicle on this subject considerable advances have been made concerning the pathology, immunohistochemistry, molecular biology and behavior of ophthalmic tumors. These are covered in detail. The more lengthy discussions concern the two most important intraocular tumors, retinoblastoma and uveal melanoma, but there is considerable attention given to those tumors that are particularly associated with this site. Among these are: the sebaceous tumors of the eyelid; the rare phakomatous choristoma of the lower eyelid, (which may be confused with an adenocarcinoma); the actinically related tumors of the conjunctiva, (keratoses, carcinomas and melanomas); the lymphomas, fibrous histiocytomas and childhood rhabdomyosarcomas of the orbit; and the melanocytoma of the optic nerve head. There are shorter discussions of extraocular tumors that have similar counterparts elsewhere in the body. The classification of tumors in this fascicle is based closely on the scheme proposed by the World Health Organization. Tables are presented that give frequencies of the various types of tumors based on the AFIP experience along with data from other registries and published series from around the world. With its 420 high-quality photographs this book should be an invaluable and indispensable source for pathologists and ophthalmologists.
Rosen: Tumors of the Mammary Gland (Vol 7)
By Paul Peter Rosen and Harold A. Oberman
1993, 382 pages, $59 list
The expanded size and scope of this third edition of Tumors of the Mammary Gland reflect the explosive growth of information relating to breast disease that has occurred in the last 25 years. The comprehensive text begins with an introduction that traces the controversial issue of precancerous or proliferative breast lesions from the first fascicle (authored in 1950 by Stewart) to the present. Nearly 25% of the 382 pages of text and 593 illustrations are devoted to the pathology of benign proliferative lesions, atypical hyperplasia, and in-situ carcinoma. The classification of mammary tumors employed in this volume is based on one adopted by the World Health Organization in 1981. However, the listing has been substantially expanded to include more than 20 specific entities described in succeeding years. Subheadings have also been added for a number of clinicopathologic conditions with distinctive pathologic characteristics such as occult carcinoma presenting with axillary lymph node metastases. The text includes sections on mammary gland anatomy, developmental and physiological abnormalities, and inflammatory conditions. Extensively illustrated sections describe benign proliferative lesions, benign epithelial tumors, fibroepithelial neoplasms (fibroadenoma and cystosarcoma), atypical hyperplasia and in-situ carcinoma of lobules and ducts, 17 subtypes of invasive carcinoma, breast tumors in children, tumors of the male breast, mesenchymal tumors, and Iymphoid neoplasms. Separate sections are devoted to the TNM staging of carcinoma, unusual clinical manifestations of breast carcinoma, the pathology of axillary lymph nodes, cytologic diagnosis of breast lesions, and the pathologic examination of breast specimens. Of particular note are discussions of papillary neoplasms, atypical hyperplasia and in-situ carcinoma, prognostic markers in carcinoma, and vascular neoplasms. The detailed histopathological descriptions consider differential diagnosis and discuss the role of immunohistochemistry, electron microscopy, and other procedures for establishing the pathologic diagnosis. The clinical characteristics of the lesions are described, and the current treatment options reported in the literature are summarized.
Kurman: Tumors of the Cervix, Vagina, and Vulva (Vol 4)
By Robert J. Kurman, Henry J. Norris and Edward J Wilkinson
1992, 262 pages, $45 list
This latest AFIP atlas reflects the progress made over the thirty years since the last fascicle on these topics appeared. There are thorough discussions of dysplasias, carcinomas, and mesenchymal tumors at the three sites. In addition, sections are devoted to the numerous tumor-like lesions that must be distinguished from neoplasms. Among these are mesodermal stromal polyp, mesonephric hyperplasia, placental-site nodule, postoperative spindle cell nodule, tubal metaplasia, and tunnel clusters. The embryology and anatomy of the lower female genital tract are summarized with the use of diagrams as well as photomicrographs. They are followed by a discussion of human papillomaviruses and cancer of the lower female genital tract. Unusual as well as common entities are described and illustrated. The authors worked with the Classification and Nomenclature Committee of the International Society of Gynecological Pathologists. Therefore, their classification and nomenclature reflect more than just their own views and will be the basis for the World Health Organization's forthcoming histological classification of tumors "blue book." There are 262 pages, 5 tables, 3 color plates, and 341 black-andwhite illustrations. The quality of both clinical and microscopic illustrations is outstanding. Gynecologists and gynecological oncologists as well as pathologists will find it indispensable.
Elder: Melanocytic Tumors of the Skin (Vol 2)
By David E. Elder and George F. Murphy
1992, 216 pages, $45 list
The new Fascicle concerning Melanocytic Tumors of the Skin follows an identical style and format as its companion on non-melanocytic skin tumors (Fascicle I in this series). Particular emphasis has been placed on presenting descriptions and diagnostic criteria for commonly encountered entities, as well as those rare disorders that often escape mention in conventional texts, e.g. neurotropic malignant melanoma, deep penetrating nevus, and nevi of genital skin. As in Fascicle 1, all disorders are presented according to their salient structural features at scanning magnification as well as at higher magnification for diagnostically critical points. Areas that readers may find particularly useful include: definitive description and clinicopathologic criteria for diagnosis of dysplastic nevi; comprehensive description of nevus and melanoma variants; an extensive discussion of Spitz nevi and variants; meaning, significance, and criteria for diagnosis of minimal deviation mela-noma; and current use of monoclonal antibodies in diagnosis of melanoma. The text is extensive and replete with comparative and summary tables, e.g. Spitz nevus vs. melanoma. The sections on malignant melanoma not only include comprehensive rosters of diagnostic and grading criteria, but also detailed charts and tables from the extensive experience of the Pigmented Lesion Study Group and Database at the University of Pennsylvania that enable prediction of outcome based on morphologic features. This model should promote precision and consistency in melanoma diagnosis, treatment, and follow-up. The clinical and microscopic illustrations are of the high quality that have been synonymous with this series. Dermatologists as well as pathologists will find it indispensable.
Murphy: Non-Melanocytic Tumors of the Skin (Vol 1)
By George F. Murphy and David E. Elder
1991, 278 pages, $45 list
Since the last AFIP Fascicle on Tumors of the Skin, three decades have witnessed revolutionary advances in dermatopathology. The new fascicle concerning non-melanocytic tumors of the skin has sought to capture the spirit of these advances and display them in a form that is user friendly. Major subject categories include tumors of: epidermal keratinocytes; cutaneous eccrine, apocrine, and pilosebaceous adnexae; hematopoietic cells; fibrohistiocytic, neural, vascular, and smooth muscle lineage; and metastatic neoplasms to skin. Up-to-date technologies relevant to practical diagnostic issues are described and illustrated, e.g., in situ hybridiza-tion for detection of specific HPV types and Southern blot analysis for determi-nation of gene rearrangements in cutaneous Iymphoma. Ample use of differential diagnostic tables and charts facilitate rapid and efficient extraction of essential information and criteria, e.g., keratoacanthoma vs. cup-shaped squamous cell carcinoma, differential diagnosis of verrucous epidermal hyperplasia, differential diagnosis of spindle cell malignancies of skin, and benign Iymphoid hyperplasia vs. Iymphoma cutis. The numerous photomicrographs are generally grouped in clusters that illustrate progressive magnifications or important histologic, side-by-side comparisons. Attempts have been made to simplify nomenclature, in spite of the extraordinary proliferation of new entities that has typified the last few decades in dermatopathology. Areas that readers may find particularly useful include: extensive discussion of adnexal carcinoma; comprehensive and technologically up-to-date evaluation of Iympho-prolifera-tive neoplasia; detailed description and illustration of Kaposi sarcoma, includ-ing evolutionary stages; new diagnostic details for neuroendocrine carcinoma; and cutaneous and subcutaneous neo-plasia in children. The quality of both clinical and microscopic illustrations is outstanding in this first fascicle of the Third Series of the AFIP Tumor Atlas. Dermatologists as well as pathologists will find it indispensable.
End of Pathology books published by AFIP
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